RARRES2 retinoic acid receptor responder 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RARRES2provided by HGNC
Official Full Name: retinoic acid receptor responder 2provided by HGNC
Primary source: HGNC:HGNC:9868
See related: Ensembl:ENSG00000106538 MIM:601973; AllianceGenome:HGNC:9868
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TIG2; HP10433
Summary: This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]
Expression: Broad expression in adrenal (RPKM 464.3), fat (RPKM 307.4) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q36.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (150338329..150341629, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (151516581..151519881, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (150035418..150038718, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chemerin promotes invasion of oral squamous cell carcinoma by stimulating IL-6 and TNF-alpha production via STAT3 activation.
Title: Chemerin promotes invasion of oral squamous cell carcinoma by stimulating IL-6 and TNF-α production via STAT3 activation.
Prognostic significance of the chemerin level in coronavirus disease 2019 patients.
Title: Prognostic significance of the chemerin level in coronavirus disease 2019 patients.
Adiponectin rs1501299 and chemerin rs17173608 gene polymorphism in children with type 1 diabetes mellitus: relation with macroangiopathy and peripheral artery disease.
Title: Adiponectin rs1501299 and chemerin rs17173608 gene polymorphism in children with type 1 diabetes mellitus: relation with macroangiopathy and peripheral artery disease.
Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.
Title: Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.
The Dual Role of Chemerin in Lung Diseases.
Title: The Dual Role of Chemerin in Lung Diseases.
RARRES2 is involved in the "lock-and-key" interactions between osteosarcoma stem cells and tumor-associated macrophages.
Title: RARRES2 is involved in the "lock-and-key" interactions between osteosarcoma stem cells and tumor-associated macrophages.
Association of RARRES2 rs17173608 gene polymorphism and serum Chemerin with acute myocardial infarction and its risk factors: A case-control study in an Iranian population.
Title: Association of RARRES2 rs17173608 gene polymorphism and serum Chemerin with acute myocardial infarction and its risk factors: A case-control study in an Iranian population.
Prognostic impact of chemerin expression in colorectal cancer: A detailed analysis based on histological components and meta-analysis.
Title: Prognostic impact of chemerin expression in colorectal cancer: A detailed analysis based on histological components and meta-analysis.
Neutrophils regulate tumor angiogenesis in oral squamous cell carcinoma and the role of Chemerin.
Title: Neutrophils regulate tumor angiogenesis in oral squamous cell carcinoma and the role of Chemerin.
Association of plasma chemerin with all-cause and disease-specific mortality - results from a population-based study.
Title: Association of plasma chemerin with all-cause and disease-specific mortality - results from a population-based study.

Submit: New GeneRIF Correction See all GeneRIFs (227)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC34814 (e-PCR)
- UniSTS:44062

G54148 (e-PCR)
- UniSTS:109385

RH48459 (e-PCR)
- UniSTS:25474

RH18192 (e-PCR)
- UniSTS:13031

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antifungal humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinoid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in platelet dense granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: retinoic acid receptor responder protein 2

Names: RAR-responsive protein TIG2; chemerin; retinoic acid receptor responder (tazarotene induced) 2; tazarotene-induced gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.