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    Zc3h14 zinc finger CCCH type containing 14 [ Mus musculus (house mouse) ]

    Gene ID: 75553, updated on 28-Apr-2024

    Summary

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    Official Symbol
    Zc3h14provided by MGI
    Official Full Name
    zinc finger CCCH type containing 14provided by MGI
    Primary source
    MGI:MGI:1919824
    See related
    Ensembl:ENSMUSG00000021012 AllianceGenome:MGI:1919824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1010001P15Rik; 1700016A15Rik; 2700069A02Rik
    Summary
    Predicted to enable poly(A) binding activity. Predicted to be involved in negative regulation of mRNA polyadenylation and regulation of mRNA stability. Located in nuclear speck. Is expressed in cerebral cortex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ZC3H14 (zinc finger CCCH-type containing 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 36.2), CNS E11.5 (RPKM 18.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 E; 12 49.88 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (98708276..98754033)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (98742017..98787774)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 7 Neighboring gene STARR-seq mESC enhancer starr_33000 Neighboring gene protein tyrosine phosphatase, non-receptor type 21 Neighboring gene STARR-positive B cell enhancer ABC_E9861 Neighboring gene echinoderm microtubule associated protein like 5 Neighboring gene predicted gene, 35463 Neighboring gene STARR-seq mESC enhancer starr_33001 Neighboring gene STARR-seq mESC enhancer starr_33002 Neighboring gene STARR-positive B cell enhancer ABC_E5348 Neighboring gene tetratricopeptide repeat domain 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Wheeler JM, et al. Sci Transl Med, 2019 Dec 18. PMID 31852801, Free PMC Article
    2. The polyadenosine RNA-binding protein ZC3H14 interacts with the THO complex and coordinately regulates the processing of neuronal transcripts. Morris KJ, et al. Nucleic Acids Res, 2018 Jul 27. PMID 29912477, Free PMC Article
    3. The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice. Rha J, et al. Hum Mol Genet, 2017 Oct 1. PMID 28666327, Free PMC Article
    4. Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein. Leung SW, et al. Gene, 2009 Jun 15. PMID 19303045, Free PMC Article
    5. Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. Pak C, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21734151, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of nuclear ZC3H14-interacting proteins from the brain and links the functions of ZC3H14 and the THO complex in the processing of RNA.
      Title: The polyadenosine RNA-binding protein ZC3H14 interacts with the THO complex and coordinately regulates the processing of neuronal transcripts.
    2. Among the proteins increased in the hippocampi of Zc3h14Deltaex13/Deltaex13 mice compared to control are key synaptic proteins including CaMK2a. This newly generated mouse serves as a tool to study the function of ZC3H14 in vivo.
      Title: The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008506.2 → NP_001008506.2  zinc finger CCCH domain-containing protein 14 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC159193, AK048046, AK076066, AK160937
      Consensus CDS
      CCDS26099.1
      UniProtKB/Swiss-Prot
      Q8BJ05
      Related
      ENSMUSP00000105731.3, ENSMUST00000110104.10
      Conserved Domains (1) summary
      pfam14608
      Location:490 → 508
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    2. NM_001160107.1 → NP_001153579.1  zinc finger CCCH domain-containing protein 14 isoform c

      See identical proteins and their annotated locations for NP_001153579.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three alternate exons in the central coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC159193, AK048046, AK076066, AK160937
      Consensus CDS
      CCDS49138.1
      UniProtKB/Swiss-Prot
      Q8BJ05
      Related
      ENSMUSP00000055879.10, ENSMUST00000057000.17
      Conserved Domains (1) summary
      pfam14608
      Location:525 → 541
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    3. NM_001160108.1 → NP_001153580.1  zinc finger CCCH domain-containing protein 14 isoform d

      See identical proteins and their annotated locations for NP_001153580.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC159193, AK006009, AK160937, BU936221
      Consensus CDS
      CCDS49139.1
      UniProtKB/Swiss-Prot
      Q8BJ05
      Related
      ENSMUSP00000021399.8, ENSMUST00000021399.9
      Conserved Domains (1) summary
      COG5084
      Location:179 → 273
      YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]

    4. NM_001364400.1 → NP_001351329.1  zinc finger CCCH domain-containing protein 14 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC159193
      Conserved Domains (1) summary
      pfam14608
      Location:677 → 693
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    5. NM_001364401.1 → NP_001351330.1  zinc finger CCCH domain-containing protein 14 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC159193
      Conserved Domains (1) summary
      pfam14608
      Location:656 → 672
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    6. NM_001364402.1 → NP_001351331.1  zinc finger CCCH domain-containing protein 14 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC159193
      Conserved Domains (1) summary
      pfam14608
      Location:546 → 562
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    7. NM_001364403.1 → NP_001351332.1  zinc finger CCCH domain-containing protein 14 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC159193
      Conserved Domains (1) summary
      pfam14608
      Location:526 → 542
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    8. NM_001364404.1 → NP_001351333.1  zinc finger CCCH domain-containing protein 14 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC159193
      Conserved Domains (1) summary
      pfam14608
      Location:395 → 411
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    9. NM_001364405.1 → NP_001351334.1  zinc finger CCCH domain-containing protein 14 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC159193
      Conserved Domains (1) summary
      pfam14608
      Location:370 → 386
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    10. NM_029334.2 → NP_083610.2  zinc finger CCCH domain-containing protein 14 isoform a

      See identical proteins and their annotated locations for NP_083610.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC159193, AK048046, AK076066, AK160937
      Consensus CDS
      CCDS26100.1
      UniProtKB/Swiss-Prot
      A0PJE7, A1A4A9, Q3TU70, Q8BIY8, Q8BJ05, Q8R3Q8, Q8R3R2, Q9DAA8
      Related
      ENSMUSP00000105732.3, ENSMUST00000110105.10
      Conserved Domains (1) summary
      pfam14608
      Location:621 → 639
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    RNA

    1. NR_027648.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 5' coding region and three alternate exons in the central coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC159193, AK076066, AK160937

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      98708276..98754033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516327.4 → XP_006516390.3  zinc finger CCCH domain-containing protein 14 isoform X1

      Conserved Domains (1) summary
      pfam14608
      Location:739 → 755
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    2. XM_006516328.4 → XP_006516391.3  zinc finger CCCH domain-containing protein 14 isoform X2

      Conserved Domains (1) summary
      pfam14608
      Location:714 → 730
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    3. XM_006516330.4 → XP_006516393.3  zinc finger CCCH domain-containing protein 14 isoform X4

      Conserved Domains (1) summary
      pfam14608
      Location:583 → 599
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    4. XM_006516329.4 → XP_006516392.3  zinc finger CCCH domain-containing protein 14 isoform X3

      Conserved Domains (1) summary
      pfam14608
      Location:608 → 624
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    5. XM_030246973.2 → XP_030102833.1  zinc finger CCCH domain-containing protein 14 isoform X5

      Conserved Domains (1) summary
      pfam14608
      Location:501 → 517
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    6. XM_006516333.3 → XP_006516396.1  zinc finger CCCH domain-containing protein 14 isoform X6

      Conserved Domains (1) summary
      pfam14608
      Location:386 → 402
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    RNA

    1. XR_001780498.2 RNA Sequence

    2. XR_001780499.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJ05.1 GenPept UniProtKB/Swiss-Prot:Q8BJ05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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