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    Cnot10 CCR4-NOT transcription complex, subunit 10 [ Mus musculus (house mouse) ]

    Gene ID: 78893, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cnot10provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 10provided by MGI
    Primary source
    MGI:MGI:1926143
    See related
    Ensembl:ENSMUSG00000056167 AllianceGenome:MGI:1926143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2600001P13Rik
    Summary
    Predicted to be involved in mRNA catabolic process and negative regulation of translation. Predicted to act upstream of or within gene silencing by RNA and regulation of translation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and white fat. Orthologous to human CNOT10 (CCR4-NOT transcription complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 25.5), CNS E11.5 (RPKM 22.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F3; 9 64.72 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114414942..114469289, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114585874..114640220, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25350 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:114419096-114419279 Neighboring gene C-C motif chemokine receptor 4 Neighboring gene tripartite motif-containing 71 Neighboring gene STARR-seq mESC enhancer starr_25364 Neighboring gene STARR-seq mESC enhancer starr_25369 Neighboring gene STARR-seq mESC enhancer starr_25371 Neighboring gene STARR-seq mESC enhancer starr_25375 Neighboring gene predicted gene, 53512 Neighboring gene STARR-positive B cell enhancer ABC_E9776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:114549332-114549515 Neighboring gene predicted gene, 51659 Neighboring gene predicted gene 7780 Neighboring gene dynein cytoplasmic 1 light intermediate chain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation. Du H, et al. J Mol Cell Biol, 2020 Oct 26. PMID 33104214, Free PMC Article
    2. Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development. Chen C, et al. Biochem Biophys Res Commun, 2011 Jul 29. PMID 21741365
    3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
      Title: RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC37693

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153585.5 → NP_705813.2  CCR4-NOT transcription complex subunit 10

      See identical proteins and their annotated locations for NP_705813.2

      Status: VALIDATED

      Source sequence(s)
      AK029103, CA537067, CX222096
      Consensus CDS
      CCDS40794.1
      UniProtKB/Swiss-Prot
      Q05CH8, Q3TSS4, Q3UDS5, Q80VN2, Q8BH15, Q8CI74
      Related
      ENSMUSP00000064840.7, ENSMUST00000070117.8
      Conserved Domains (2) summary
      COG0457
      Location:59 → 274
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:296 → 321
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      114414942..114469289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155411.1 → XP_036011304.1  CCR4-NOT transcription complex subunit 10 isoform X4

      Conserved Domains (1) summary
      sd00006
      Location:296 → 321
      TPR; TPR repeat [structural motif]

    2. XM_030244727.2 → XP_030100587.1  CCR4-NOT transcription complex subunit 10 isoform X3

      Conserved Domains (1) summary
      sd00006
      Location:296 → 321
      TPR; TPR repeat [structural motif]

    3. XM_006512399.4 → XP_006512462.1  CCR4-NOT transcription complex subunit 10 isoform X1

      See identical proteins and their annotated locations for XP_006512462.1

      UniProtKB/Swiss-Prot
      Q8BH15
      Conserved Domains (1) summary
      sd00006
      Location:296 → 321
      TPR; TPR repeat [structural motif]

    4. XM_017313699.2 → XP_017169188.1  CCR4-NOT transcription complex subunit 10 isoform X2

      Conserved Domains (1) summary
      sd00006
      Location:296 → 321
      TPR; TPR repeat [structural motif]

    RNA

    1. XR_003948060.2 RNA Sequence

    2. XR_003948061.2 RNA Sequence

      Related
      ENSMUST00000215155.2

    3. XR_003948062.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH15.1 GenPept UniProtKB/Swiss-Prot:Q8BH15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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