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    SGD1 Sgd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851049, updated on 13-Apr-2024

    Summary

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    Gene symbol
    SGD1
    Gene description
    Sgd1p
    Primary source
    SGD:S000004328
    Locus tag
    YLR336C
    See related
    AllianceGenome:SGD:S000004328
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in hyperosmotic response and ribosomal small subunit biogenesis. Located in nucleolus. Part of FAL1-SGD1 complex. Orthologous to human NOM1 (nucleolar protein with MIF4G domain 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (799697..802396, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene nucleoporin NUP2 Neighboring gene Vrp1p Neighboring gene ribosomal protein P0

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia. Simmons HM, et al. Gene, 2005 Feb 28. PMID 15715967
    2. Phospholipase C interacts with Sgd1p and is required for expression of GPD1 and osmoresistance in Saccharomyces cerevisiae. Lin H, et al. Mol Genet Genomics, 2002 May. PMID 12073033
    3. SGD1 encodes an essential nuclear protein of Saccharomyces cerevisiae that affects expression of the GPD1 gene for glycerol 3-phosphate dehydrogenase. Akhtar N, et al. FEBS Lett, 2000 Oct 20. PMID 11042259
    4. Sgd1 is an MIF4G domain-containing cofactor of the RNA helicase Fal1 and associates with the 5' domain of the 18S rRNA sequence. Davila Gallesio J, et al. RNA Biol, 2020 Apr. PMID 31994962, Free PMC Article
    5. Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex. Alexandrov A, et al. Genes Dev, 2011 May 15. PMID 21576267, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sgd1 is an MIF4G domain-containing cofactor of the RNA helicase Fal1 and associates with the 5' domain of the 18S rRNA sequence.
      Title: Sgd1 is an MIF4G domain-containing cofactor of the RNA helicase Fal1 and associates with the 5' domain of the 18S rRNA sequence.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in hyperosmotic response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAL1-SGD1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sgd1p
    NP_013440.1
    • Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      799697..802396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182225.1 → NP_013440.1  TPA: Sgd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYX6, Q06132
      UniProtKB/TrEMBL
      G2WJF5, N1P1M7
      Conserved Domains (3) summary
      PTZ00121
      Location:23 → 337
      PTZ00121; MAEBL; Provisional
      pfam02847
      Location:645 → 771
      MA3; MA3 domain
      pfam02854
      Location:336 → 540
      MIF4G; MIF4G domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06132.1

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