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    PUT2 1-pyrroline-5-carboxylate dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856432, updated on 13-Apr-2024

    Summary

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    Gene symbol
    PUT2
    Gene description
    1-pyrroline-5-carboxylate dehydrogenase
    Primary source
    SGD:S000001079
    Locus tag
    YHR037W
    See related
    AllianceGenome:SGD:S000001079
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 1-pyrroline-5-carboxylate dehydrogenase activity. Involved in glutamate biosynthetic process and proline catabolic process to glutamate. Located in mitochondrial matrix. Used to study disease of metabolism. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (181977..183704)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein NEL1 Neighboring gene Brl1p Neighboring gene Rrf1p Neighboring gene meiotic recombination directing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the yeast acetyltransferase Mpr1 in oxidative stress: regulation of oxygen reactive species caused by a toxic proline catabolism intermediate. Nomura M, et al. Proc Natl Acad Sci U S A, 2004 Aug 24. PMID 15308773, Free PMC Article
    2. Proline utilization in Saccharomyces cerevisiae: analysis of the cloned PUT2 gene. Brandriss MC. Mol Cell Biol, 1983 Oct. PMID 6358862, Free PMC Article
    3. Primary structure of the nuclear PUT2 gene involved in the mitochondrial pathway for proline utilization in Saccharomyces cerevisiae. Krzywicki KA, et al. Mol Cell Biol, 1984 Dec. PMID 6098824, Free PMC Article
    4. Inhibition of yeast 1 -pyrroline-5-carboxylate dehydrogenase by common amino acids and the regulation of proline catabolism. Lundgren DW, et al. Biochim Biophys Acta, 1973 Feb 28. PMID 4145181
    5. Amino-terminal fragments of delta 1-pyrroline-5-carboxylate dehydrogenase direct beta-galactosidase to the mitochondrial matrix in Saccharomyces cerevisiae. Brandriss MC, et al. Mol Cell Biol, 1986 Oct. PMID 3025596, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. active site flexibility and oligomeric state of Delta(1)-pyrroline-5-carboxylate dehydrogenase
      Title: Structural studies of yeast Δ(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): active site flexibility and oligomeric state.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proline catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proline catabolic process to glutamate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline catabolic process to glutamate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proline metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-pyrroline-5-carboxylate dehydrogenase
    NP_011902.1
    • Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      181977..183704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179167.1 → NP_011902.1  TPA: 1-pyrroline-5-carboxylate dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKY4, P07275
      UniProtKB/TrEMBL
      A0A8H4C192, A6ZSU3, B3LSF7, C7GTU3, C8ZAA7, G2WFA9, N1P2U9
      Conserved Domains (1) summary
      TIGR01236
      Location:29 → 574
      D1pyr5carbox1; delta-1-pyrroline-5-carboxylate dehydrogenase, group 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07275.2

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