U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Otud5 OTU deubiquitinase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363452, updated on 13-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Otud5provided by RGD
    Official Full Name
    OTU deubiquitinase 5provided by RGD
    Primary source
    RGD:1563027
    See related
    Ensembl:ENSRNOG00000008764 AllianceGenome:RGD:1563027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent deubiquitinase. Predicted to be involved in several processes, including positive regulation of TOR signaling; protein deubiquitination; and response to lipopolysaccharide. Predicted to act upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 267.8), Spleen (RPKM 221.3) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Otud5 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17296750..17331257, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14626173..14659331, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15471212..15504372, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member A2 Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase Neighboring gene solute carrier family 25 member 39, pseudogene 6 Neighboring gene potassium voltage-gated channel subfamily D member 1 Neighboring gene GRIP1 associated protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phosphorylation-dependent activity of the deubiquitinase DUBA. Huang OW, et al. Nat Struct Mol Biol, 2012 Jan 15. PMID 22245969
    2. DUBA: a deubiquitinase that regulates type I interferon production. Kayagaki N, et al. Science, 2007 Dec 7. PMID 17991829
    3. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Rutz S, et al. Nature, 2015 Feb 19. PMID 25470037
    4. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Mevissen TE, et al. Cell, 2013 Jul 3. PMID 23827681, Free PMC Article
    5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K48-linked deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K63-linked deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T-helper 17 cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural crest cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural crest cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural crest cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC2 signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of T-helper 17 type immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    OTU domain-containing protein 5
    Names
    DUBA
    OTU domain containing 5
    deubiquinating enzyme A
    deubiquitinating enzyme A
    NP_001032585.1
    NP_001401659.1
    XP_006256799.1
    XP_006256802.1
    XP_006256803.1
    XP_063136188.1
    XP_063136189.1
    XP_063136190.1
    XP_063136191.1
    XP_063136192.1
    XP_063136193.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037496.1 → NP_001032585.1  OTU domain-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001032585.1

      Status: PROVISIONAL

      Source sequence(s)
      BC110054
      UniProtKB/TrEMBL
      A6KP74
      Conserved Domains (1) summary
      cl19932
      Location:178 → 287
      OTU; OTU-like cysteine protease

    2. NM_001414730.1 → NP_001401659.1  OTU domain-containing protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q2YDU3
      Related
      ENSRNOP00000080452.1, ENSRNOT00000113203.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17296750..17331257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256737.5 → XP_006256799.1  OTU domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAB2, A6KP75
      Related
      ENSRNOP00000090218.1
      Conserved Domains (1) summary
      cl19932
      Location:294 → 403
      OTU; OTU-like cysteine protease

    2. XM_063280120.1 → XP_063136190.1  OTU domain-containing protein 5 isoform X4

    3. XM_006256741.5 → XP_006256803.1  OTU domain-containing protein 5 isoform X6

      UniProtKB/TrEMBL
      A0A0H2UHD0, A6KP74
      Related
      ENSRNOP00000006233.6
      Conserved Domains (1) summary
      cl19932
      Location:251 → 360
      OTU; OTU-like cysteine protease

    4. XM_006256740.5 → XP_006256802.1  OTU domain-containing protein 5 isoform X5

      UniProtKB/TrEMBL
      A6KP74
      Conserved Domains (1) summary
      cl19932
      Location:251 → 360
      OTU; OTU-like cysteine protease

    5. XM_063280121.1 → XP_063136191.1  OTU domain-containing protein 5 isoform X7

    6. XM_063280119.1 → XP_063136189.1  OTU domain-containing protein 5 isoform X3

    7. XM_063280118.1 → XP_063136188.1  OTU domain-containing protein 5 isoform X2

    8. XM_063280122.1 → XP_063136192.1  OTU domain-containing protein 5 isoform X8

    9. XM_063280123.1 → XP_063136193.1  OTU domain-containing protein 5 isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2YDU3.2 GenPept UniProtKB/Swiss-Prot:Q2YDU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous