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    Isg20l2 interferon stimulated exonuclease gene 20-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361977, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Isg20l2provided by RGD
    Official Full Name
    interferon stimulated exonuclease gene 20-like 2provided by RGD
    Primary source
    RGD:1359413
    See related
    Ensembl:ENSRNOG00000011402 AllianceGenome:RGD:1359413
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic and ribosome biogenesis. Predicted to be located in nucleolus. Predicted to be active in nucleus. Orthologous to human ISG20L2 (interferon stimulated exonuclease gene 20 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 159.2), Thymus (RPKM 136.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Isg20l2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175694638..175704125)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173396780..173407102)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187302192..187311677)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene heparin binding growth factor Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene methyltransferase like 25B Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene nestin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis. Couté Y, et al. Mol Cell Proteomics, 2008 Mar. PMID 18065403
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC94465

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon-stimulated 20 kDa exonuclease-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007741.1 → NP_001007742.1  interferon-stimulated 20 kDa exonuclease-like 2

      See identical proteins and their annotated locations for NP_001007742.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079314
      UniProtKB/Swiss-Prot
      Q6AXU3
      UniProtKB/TrEMBL
      A0A8I6GML8, A6J637
      Related
      ENSRNOP00000015471.4, ENSRNOT00000015471.5
      Conserved Domains (1) summary
      cd06149
      Location:196 → 352
      ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      175694638..175704125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102657.2 → XP_038958585.1  interferon-stimulated 20 kDa exonuclease-like 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXU3
      UniProtKB/TrEMBL
      A0A8I6GML8, A6J637
      Conserved Domains (1) summary
      cd06149
      Location:196 → 352
      ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXU3.1 GenPept UniProtKB/Swiss-Prot:Q6AXU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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