Gmpr guanosine monophosphate reductase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gmprprovided by RGD
Official Full Name: guanosine monophosphate reductaseprovided by RGD
Primary source: RGD:70980
See related: Ensembl:ENSRNOG00000017250 AllianceGenome:RGD:70980
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gmpr1; GMPR 1
Summary: Predicted to enable GMP reductase activity and metal ion binding activity. Involved in response to cold. Predicted to be part of GMP reductase complex. Orthologous to human GMPR (guanosine monophosphate reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 574.3), Muscle (RPKM 561.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (19357992..19395807, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (19151820..19189626, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (19543274..19580929, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI138122 (e-PCR)
- UniSTS:261208

BF397915 (e-PCR)
- UniSTS:246385

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GMP reductase activity	IEA Inferred from Electronic Annotation more info
enables GMP reductase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GMP reductase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GMP reductase 1

Names: guanosine 5'-monophosphate oxidoreductase 1; guanosine monophosphate reductase 1

NP_476536.2

EC 1.7.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057188.2 → NP_476536.2 GMP reductase 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q9Z244

UniProtKB/TrEMBL

F1LRV6

Related

ENSRNOP00000023613.3, ENSRNOT00000023613.5

Conserved Domains (1) summary

TIGR01305
Location:3 → 344

GMP_reduct_1; guanosine monophosphate reductase, eukaryotic