Lat2 linker for activation of T cells family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lat2provided by MGI
Official Full Name: linker for activation of T cells family, member 2provided by MGI
Primary source: MGI:MGI:1926479
See related: Ensembl:ENSMUSG00000040751 AllianceGenome:MGI:1926479
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LAB; NTAL; WSCR5; Wbscr5; Wbscr15
Summary: Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to act upstream of or within adaptive immune response and mast cell degranulation. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 8.2), mammary gland adult (RPKM 2.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 74.7 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (134628957..134648637, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (134600103..134619783, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NTAL is a key inhibitor of mast cell chemotaxis toward PGE2, which may act through the RHOA/ERM/beta1-integrin and PI3K/AKT axes
Title: The transmembrane adaptor protein NTAL limits mast cell chemotaxis toward prostaglandin E(2).
NTAL is a negative regulator of FcepsilonRI activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations.
Title: Multiple regulatory roles of the mouse transmembrane adaptor protein NTAL in gene transcription and mast cell physiology.
Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation.
Title: Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation.
Our data define a novel link between LAB and beta-catenin nuclear accumulation in dendritic cells that facilitates IFN-gamma responses during anti-fungal immunity
Title: LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family
Title: Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
Dihydrotestosterone treatment increased the expression of LAT2.
Title: Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism.
Our study suggested a novel mechanism by which LAB functions in the regulation of innate immunity
Title: Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB.
The expression of Mct8 and L-type amino acid transporters Lat2 and Lat1 are determined in brain neurons during development.
Title: Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells.
a crucial role of NTAL in signaling, via RhoA, to mast cell cytoskeleton.
Title: The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho.
While SLP-76 and LAT1 depend on each other for many of their functions, LAT2/SLP-76 interactions and SLP-76-independent LAT1 functions also mediate a positive signaling pathway downstream of FcepsilonRI in mast cells.
Title: Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW125574 (e-PCR)
- UniSTS:179282

Wbscr5 (e-PCR), detects polymorphism
- UniSTS:186555

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in B cell activation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in immune response-regulating signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mast cell degranulation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: linker for activation of T-cells family member 2

Names: Williams-Beuren syndrome chromosome region 5 homolog; linker for activation of B-cells; membrane-associated adapter molecule; non-T cell activation linker; williams-Beuren syndrome chromosomal region 15 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020044.3 → NP_064428.1 linker for activation of T-cells family member 2 isoform a

See identical proteins and their annotated locations for NP_064428.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK138953, AK143533

Consensus CDS

CCDS39312.1

UniProtKB/Swiss-Prot

Q3UYF6, Q9JHL0, Q9JJ29

Related

ENSMUSP00000046900.7, ENSMUST00000036362.13

Conserved Domains (1) summary

pfam15703
Location:29 → 197

LAT2; Linker for activation of T-cells family member 2
NM_022964.4 → NP_075253.2 linker for activation of T-cells family member 2 isoform b

See identical proteins and their annotated locations for NP_075253.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.

Source sequence(s)

AK138953, AK143533, AK162321

Consensus CDS

CCDS39311.1

UniProtKB/Swiss-Prot

Q9JHL0

Related

ENSMUSP00000076824.5, ENSMUST00000077636.8

Conserved Domains (1) summary

pfam15703
Location:29 → 185

LAT2; Linker for activation of T-cells family member 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

134628957..134648637 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504456.5 → XP_006504519.1 linker for activation of T-cells family member 2 isoform X5

Conserved Domains (1) summary

pfam15703
Location:43 → 138

LAT2; Linker for activation of T-cells family member 2
XM_006504455.4 → XP_006504518.1 linker for activation of T-cells family member 2 isoform X4

Conserved Domains (1) summary

pfam15703
Location:80 → 162

LAT2; Linker for activation of T-cells family member 2
XM_006504453.4 → XP_006504516.1 linker for activation of T-cells family member 2 isoform X3

Conserved Domains (1) summary

pfam15703
Location:92 → 174

LAT2; Linker for activation of T-cells family member 2
XM_006504451.4 → XP_006504514.1 linker for activation of T-cells family member 2 isoform X1

See identical proteins and their annotated locations for XP_006504514.1

UniProtKB/Swiss-Prot

Q3UYF6, Q9JHL0, Q9JJ29

Conserved Domains (1) summary

pfam15703
Location:29 → 197

LAT2; Linker for activation of T-cells family member 2
XM_006504452.2 → XP_006504515.1 linker for activation of T-cells family member 2 isoform X2

See identical proteins and their annotated locations for XP_006504515.1

UniProtKB/Swiss-Prot

Q9JHL0

Conserved Domains (1) summary

pfam15703
Location:29 → 185

LAT2; Linker for activation of T-cells family member 2
XM_006504450.2 → XP_006504513.1 linker for activation of T-cells family member 2 isoform X1

See identical proteins and their annotated locations for XP_006504513.1

UniProtKB/Swiss-Prot

Q3UYF6, Q9JHL0, Q9JJ29

Related

ENSMUSP00000143977.2, ENSMUST00000200998.4

Conserved Domains (1) summary

pfam15703
Location:29 → 197

LAT2; Linker for activation of T-cells family member 2