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    Mafg MAF bZIP transcription factor G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64188, updated on 2-May-2024

    Summary

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    Official Symbol
    Mafgprovided by RGD
    Official Full Name
    MAF bZIP transcription factor Gprovided by RGD
    Primary source
    RGD:619953
    See related
    Ensembl:ENSRNOG00000036697 AllianceGenome:RGD:619953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in regulation of cellular pH. Predicted to be active in nucleus. Orthologous to human MAFG (MAF bZIP transcription factor G). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 74.3), Kidney (RPKM 63.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mafg in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106401633..106410159, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105903307..105911808, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109802877..109811476, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene sirtuin 7 Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene myeloid-associated differentiation marker-like 2 Neighboring gene NOTUM, palmitoleoyl-protein carboxylesterase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MafG-2 is a novel Maf protein that is expressed by stimulation of extracellular H(+). Shimokawa N, et al. Cell Signal, 2001 Nov. PMID 11583919
    2. Cloning of MafG homologue from the rat brain by differential display and its expression after hypercapnic stimulation. Shimokawa N, et al. Mol Cell Biochem, 2000 Jan. PMID 10724342
    3. Extracellular acidification enhances DNA binding activity of MafG-FosB heterodimer. Shimokawa N, et al. J Cell Physiol, 2005 Oct. PMID 15828020
    4. Nrf2 transcriptionally activates the mafG gene through an antioxidant response element. Katsuoka F, et al. J Biol Chem, 2005 Feb 11. PMID 15574414
    5. Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice. Shavit JA, et al. Genes Dev, 1998 Jul 15. PMID 9679061, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the up-regulation of TCF11/MafG binding could be suppressed by overexpression of the TGF-beta inhibitor Smad7, and a small interfering RNA to TCF11 blocked the suppression of iNOS by TGF-beta.
      Title: Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11.
    2. MafG-FBJ osteosarcoma oncogene B complexes are involved in transcriptional regulation in response to extracellular acidification
      Title: Extracellular acidification enhances DNA binding activity of MafG-FosB heterodimer.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of epidermal cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of epidermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor MafG
    Names
    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022386.4 → NP_071781.1  transcription factor MafG

      See identical proteins and their annotated locations for NP_071781.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      Conserved Domains (1) summary
      cd14717
      Location:46 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106401633..106410159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269808.1 → XP_063125878.1  transcription factor MafG isoform X2

      UniProtKB/Swiss-Prot
      Q76MX4, Q99N83
      UniProtKB/TrEMBL
      A6HLH1

    2. XM_063269811.1 → XP_063125881.1  transcription factor MafG isoform X3

    3. XM_039086788.2 → XP_038942716.1  transcription factor MafG isoform X3

      Conserved Domains (1) summary
      cd14717
      Location:46 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    4. XM_006247921.5 → XP_006247983.1  transcription factor MafG isoform X3

      See identical proteins and their annotated locations for XP_006247983.1

      Conserved Domains (1) summary
      cd14717
      Location:46 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    5. XM_063269810.1 → XP_063125880.1  transcription factor MafG isoform X2

      UniProtKB/Swiss-Prot
      Q76MX4, Q99N83
      UniProtKB/TrEMBL
      A6HLH1

    6. XM_039086787.2 → XP_038942715.1  transcription factor MafG isoform X3

      Conserved Domains (1) summary
      cd14717
      Location:46 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    7. XM_063269809.1 → XP_063125879.1  transcription factor MafG isoform X2

      UniProtKB/Swiss-Prot
      Q76MX4, Q99N83
      UniProtKB/TrEMBL
      A6HLH1

    8. XM_006247922.5 → XP_006247984.1  transcription factor MafG isoform X3

      See identical proteins and their annotated locations for XP_006247984.1

      Conserved Domains (1) summary
      cd14717
      Location:46 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    9. XM_063269807.1 → XP_063125877.1  transcription factor MafG isoform X2

      UniProtKB/Swiss-Prot
      Q76MX4, Q99N83
      UniProtKB/TrEMBL
      A6HLH1

    10. XM_006247913.5 → XP_006247975.1  transcription factor MafG isoform X1

      UniProtKB/TrEMBL
      A0A8L2QQP9
      Related
      ENSRNOP00000051853.2
      Conserved Domains (1) summary
      cd14717
      Location:103 → 172
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    11. XM_008768482.4 → XP_008766704.1  transcription factor MafG isoform X3

      See identical proteins and their annotated locations for XP_008766704.1

      Conserved Domains (1) summary
      cd14717
      Location:46 → 115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76MX4.2 GenPept UniProtKB/Swiss-Prot:Q76MX4

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