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    flw flapwing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44289, updated on 26-Apr-2024

    Summary

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    Official Symbol
    flwprovided by FlyBase
    Official Full Name
    flapwingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000711
    Locus tag
    Dmel_CG2096
    See related
    AllianceGenome:FB:FBgn0000711
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.120; CG15305; CG2096; Dmel\CG2096; DmPp1-9C; FLW; FLW/PP1B; l(1)G0172; PP-1; PP-1c; PP1; PP1 9C; PP1 b9C; PP1 beta9c; Pp1-9C; PP19C; PP1beta; Pp1beta-9C; PP1beta-9C; Pp1beta9C; PP1beta9C; PP1B_DROME; PP1c; PP1cbeta; XE55
    Summary
    Enables myosin phosphatase activity. Involved in several processes, including oogenesis; regulation of actomyosin contractile ring contraction; and regulation of signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic/larval dorsal vessel; embryonic/larval muscle system; and ovariole. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    9B14-9C1; 1-31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10385960..10409817)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10279993..10303850)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Partner of Sld Five 3 Neighboring gene uncharacterized protein Neighboring gene RabX2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. When proteome meets genome: the alpha helix and the beta strand of proteins are eschewed by mRNA splice junctions and may define the minimal indivisible modules of protein architecture. Barik S. J Biosci, 2004 Sep. PMID 15381847, Free PMC Article
    2. PP1beta9C interacts with Trithorax in Drosophila wing development. Rudenko A, et al. Dev Dyn, 2004 Oct. PMID 15366010
    3. Vectors for the expression of tagged proteins in Drosophila. Parker L, et al. Biotechniques, 2001 Dec. PMID 11768656
    4. Myosin light-chain phosphatase regulates basal actomyosin oscillations during morphogenesis. Valencia-Expósito A, et al. Nat Commun, 2016 Feb 18. PMID 26888436, Free PMC Article
    5. Developmental and genetic studies of the indirect flight muscles of Drosophila melanogaster. Deak II, et al. Basic Life Sci, 1980. PMID 6779791

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. flw is a key regulator of basal myosin oscillations and cell contractions underlying egg chamber elongation.
      Title: Myosin light-chain phosphatase regulates basal actomyosin oscillations during morphogenesis.
    2. Flw functions together with myosin phosphatase 1beta to negatively regulate myosin activity during ring canal formation in oogenesis.
      Title: Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation.
    3. Drosophila melanogaster protein phosphatase type 1 beta (flapwing) co-regulates dephosphorylation and altered activity of both Merlin and Moesin.
      Title: The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila.
    4. identified a loss-of-function mutation of flapwing, which encodes the catalytic subunit of protein phosphatase 1beta (PP1beta) that disrupts oocyte polarization
      Title: Regulation of somatic myosin activity by protein phosphatase 1β controls Drosophila oocyte polarization.
    5. Overexpression of the PP1 alpha isozymes does not rescue semilethal PP1 beta 9C mutants, whereas overexpression of either PP1 alpha 96A or PP1 beta 9C does rescue a lethal PP1 alpha 87B mutant combination.
      Title: Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes.
    6. a Jun N-terminal kinase (JNK) mutant suppresses the semilethality of a strong flw allele
      Title: The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila.
    7. Data show that Drosophila PP1beta, a specific isoform of serine/threonine protein phosphatase 1 (PP1), regulates nonmuscle myosin and that this is the essential role of PP1beta.
      Title: The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin.
    8. Results suggest that protein phosphatase 1beta9C and Trithorax cooperate in Drosophila wing development.
      Title: PP1beta9C interacts with Trithorax in Drosophila wing development.
    9. nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1c) interact in vivo in Drosophila
      Title: Functional interaction between nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1) in Drosophila: consequences of over-expression of NIPP1 in flies and suppression by co-expression of PP1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germline ring canal formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ovarian nurse cell to oocyte transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in striated muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    flapwing
    Names
    CG2096-PA
    CG2096-PB
    CG2096-PC
    CG2096-PD
    PP1beta9C
    flap wing
    flw-PA
    flw-PB
    flw-PC
    flw-PD
    protein phosphatase 1
    protein phosphatase 1beta at 9C
    NP_001259407.1
    NP_001356939.1
    NP_524738.1
    NP_727418.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10385960..10409817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272478.1 → NP_001259407.1  flapwing, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259407.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48462, Q9W2V5
      UniProtKB/TrEMBL
      H5V895, Q8SWU9
      Conserved Domains (1) summary
      cd07414
      Location:7 → 297
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    2. NM_167229.2 → NP_727418.1  flapwing, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727418.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0U6, Q9W2V6
      Related
      FBpp0071381
      Conserved Domains (2) summary
      smart00156
      Location:160 → 430
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07414
      Location:149 → 428
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    3. NM_001369992.1 → NP_001356939.1  flapwing, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K293, Q8SWU9
      Conserved Domains (1) summary
      cd07414
      Location:7 → 297
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    4. NM_079999.3 → NP_524738.1  flapwing, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524738.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48462, Q9W2V5
      UniProtKB/TrEMBL
      H5V895, Q8SWU9
      Related
      FBpp0071382
      Conserved Domains (1) summary
      cd07414
      Location:7 → 297
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K293 A0A4D6K293
    H5V895 H5V895
    P48462.1 P48462
    Q8SWU9 Q8SWU9
    Q8T0U6 Q8T0U6

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