Pln phospholamban [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plnprovided by RGD
Official Full Name: phospholambanprovided by RGD
Primary source: RGD:619894
See related: AllianceGenome:RGD:619894
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Plm
Summary: Enables ATPase inhibitor activity and identical protein binding activity. Involved in several processes, including response to insulin; response to testosterone; and response to zinc ion. Located in sarcoplasmic reticulum and vesicle. Part of protein-containing complex. Used to study congestive heart failure; heart disease; and myocardial infarction. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 9042.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (33166512..33182241)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (32629537..32639559)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (34633157..34642904)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myocardial Dysfunction in Cirrhotic Cardiomyopathy is Associated with Alterations of Phospholamban Phosphorylation and IL-6 Levels.
Title: Myocardial Dysfunction in Cirrhotic Cardiomyopathy is Associated with Alterations of Phospholamban Phosphorylation and IL-6 Levels.
Cardioprotection by PKN1 is associated with reduced CamKIIdelta-dependent phospholamban Thr17 phosphorylation at the SR and therefore may stabilize the coupling of SR Ca2+ handling and contractile function, independent of its kinase activity.
Title: Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury.
Long-term in vivo administration of GTE improves cell mechanical properties and intracellular calcium dynamics in normal cardiomyocytes, by increasing energy availability and removing the inhibitory effect of PLB on SERCA2.
Title: Long-Term Oral Administration of Theaphenon-E Improves Cardiomyocyte Mechanics and Calcium Dynamics by Affecting Phospholamban Phosphorylation and ATP Production.
SERCA2a and the PKA/PLN pathway are inhibited by TSH in rat cardiomyocytes
Title: TSH inhibits SERCA2a and the PKA/PLN pathway in rat cardiomyocytes.
results confirm that AKAP7gamma/delta binding to PLB is important for phosphorylation of PLB.
Title: Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation.
In reperfused control hearts, inhibition of phospholamban phosphorylation or SERCA (thapsigargin) simulated the cardioprotective effects of ischaemic post-conditioning
Title: Delayed phospholamban phosphorylation in post-conditioned heart favours Ca2+ normalization and contributes to protection.
Diminished phosphorylation of phospholamban by anthrax lethal toxin resulted in acute diastolic heart failure.
Title: Anthrax lethal toxin induces acute diastolic dysfunction in rats through disruption of the phospholamban signaling network.
The amount of sarcoplasmic reticulum Ca2+-ATPase (SERCA) 2a and phospholamban (PLB) protein was decreased and that may play a role in the diastolic dysfunction in SHRSP fatty rats.
Title: Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction.
Cardiac function and phosphorylation of PLB and cTnI were compared in pacing, isoproterenol treatment, and combined pacing and isoproterenol treatment in isolated working heart.
Title: Synergistic effects between phosphorylation of phospholamban and troponin I promote relaxation at higher heart rate.
the nNOS-PMCA4b complex regulates contractility via cAMP and phosphorylation of both PLB and cTnI.
Title: Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133632 (e-PCR)
- UniSTS:216915

RH140536 (e-PCR)
- UniSTS:222605

BE100029 (e-PCR)
- UniSTS:249766

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in acrosome assembly	ISO Inferred from Sequence Orthology more info
involved_in acrosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATPase-coupled calcium transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of calcium ion import into sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of calcium ion import into sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion import into sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart rate	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of heart rate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of relaxation of muscle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of the force of heart contraction by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to zinc ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of calcium ion-transporting ATPase complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cardiac phospholamban

Names: PLB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022707.2 → NP_073198.1 cardiac phospholamban

See identical proteins and their annotated locations for NP_073198.1

Status: VALIDATED

Source sequence(s)

CK356371, FM050525, FM055105, FM056997, FM111426

UniProtKB/Swiss-Prot

P61016

UniProtKB/TrEMBL

A6K492

Conserved Domains (1) summary

TIGR01294
Location:1 → 52

P_lamban; phospholamban

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

33166512..33182241

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099053.2 → XP_038954981.1 cardiac phospholamban isoform X1

UniProtKB/Swiss-Prot

P61016

UniProtKB/TrEMBL

A6K492

Conserved Domains (1) summary

TIGR01294
Location:1 → 52

P_lamban; phospholamban