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    Nmt1 N-myristoyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18107, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nmt1provided by MGI
    Official Full Name
    N-myristoyltransferase 1provided by MGI
    Primary source
    MGI:MGI:102579
    See related
    Ensembl:ENSMUSG00000020936 AllianceGenome:MGI:102579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables glycylpeptide N-tetradecanoyltransferase activity. Acts upstream of or within N-terminal protein myristoylation and in utero embryonic development. Predicted to be located in cytosol and plasma membrane. Predicted to be extrinsic component of membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; heart; liver; lung; and metanephros. Orthologous to human NMT1 (N-myristoyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 40.2), testis adult (RPKM 33.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E1; 11 66.71 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102919163..102959734)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103028344..103068912)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34620 Neighboring gene STARR-seq mESC enhancer starr_30823 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene microRNA 6931 Neighboring gene STARR-positive B cell enhancer ABC_E8458 Neighboring gene STARR-positive B cell enhancer ABC_E7071 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102889625-102889808 Neighboring gene STARR-seq mESC enhancer starr_30825 Neighboring gene predicted gene, 42090 Neighboring gene phospholipase C, delta 3 Neighboring gene STARR-seq mESC enhancer starr_30831 Neighboring gene STARR-positive B cell enhancer ABC_E204 Neighboring gene acyl-Coenzyme A binding domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NMT1 Enhances the Stemness of NSCLC Cells by Activating the PI3K/AKT Pathway. Zou W, et al. Pharmacology, 2022. PMID 35732157
    2. Requirement of N-myristoyltransferase 1 in the development of monocytic lineage. Shrivastav A, et al. J Immunol, 2008 Jan 15. PMID 18178842
    3. Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation. Rampoldi F, et al. J Immunol, 2015 Nov 1. PMID 26423150
    4. Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells. Rampoldi F, et al. J Leukoc Biol, 2017 Apr. PMID 28062573
    5. Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis. Hance N, et al. Hum Mol Genet, 2005 Jul 1. PMID 15888483

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMT1 Enhances the Stemness of NSCLC Cells by Activating the PI3K/AKT Pathway.
      Title: NMT1 Enhances the Stemness of NSCLC Cells by Activating the PI3K/AKT Pathway.
    2. NMT1 is essential for proper monocytic differentiation of the mouse bone marrow cells.
      Title: Requirement of N-myristoyltransferase 1 in the development of monocytic lineage.
    3. Nmt1 is not essential for the viability of mammalian cells but is required for development and is the principal N-myristoyltransferase in early embryogenesis
      Title: N-myristoyltransferase 1 is essential in early mouse development.
    4. NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation
      Title: Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycylpeptide N-tetradecanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables glycylpeptide N-tetradecanoyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables myristoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-lysine N6-myristoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-glycine N-myristoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within N-terminal peptidyl-glycine N-myristoylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in N-terminal peptidyl-glycine N-myristoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within N-terminal protein myristoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular ketone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycylpeptide N-tetradecanoyltransferase 1
    Names
    NMT 1
    myristoyl-CoA:protein N-myristoyltransferase 1
    peptide N-myristoyltransferase 1
    type I N-myristoyltransferase
    NP_032733.1
    XP_006532508.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008707.4 → NP_032733.1  glycylpeptide N-tetradecanoyltransferase 1

      See identical proteins and their annotated locations for NP_032733.1

      Status: VALIDATED

      Source sequence(s)
      AL731805
      Consensus CDS
      CCDS25511.1
      UniProtKB/Swiss-Prot
      O70310
      UniProtKB/TrEMBL
      Q3UJC3
      Related
      ENSMUSP00000021314.8, ENSMUST00000021314.8
      Conserved Domains (1) summary
      COG5092
      Location:86 → 484
      NMT1; N-myristoyl transferase [Lipid metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102919163..102959734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532445.5 → XP_006532508.1  glycylpeptide N-tetradecanoyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006532508.1

      UniProtKB/Swiss-Prot
      O70310
      UniProtKB/TrEMBL
      Q3UJC3
      Conserved Domains (1) summary
      COG5092
      Location:86 → 484
      NMT1; N-myristoyl transferase [Lipid metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70310.1 GenPept UniProtKB/Swiss-Prot:O70310

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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