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    Smu1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) [ Mus musculus (house mouse) ]

    Gene ID: 74255, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Smu1provided by MGI
    Official Full Name
    smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)provided by MGI
    Primary source
    MGI:MGI:1915546
    See related
    Ensembl:ENSMUSG00000028409 AllianceGenome:MGI:1915546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bwd; 2600001O03Rik; 2610203K23Rik
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleus. Predicted to be part of U2-type precatalytic spliceosome. Is expressed in several structures, including central nervous system; genitourinary system; liver; otocyst; and retina. Orthologous to human SMU1 (SMU1 DNA replication regulator and spliceosomal factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 30.9), placenta adult (RPKM 27.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A5; 4 20.46 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40735649..40757885, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40735649..40757885, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1272 Neighboring gene predicted gene 6297 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1 Neighboring gene microRNA 207 Neighboring gene STARR-positive B cell enhancer ABC_E7962 Neighboring gene STARR-positive B cell enhancer ABC_E4617 Neighboring gene STARR-seq mESC enhancer starr_09993 Neighboring gene presenilin enhancer gamma secretase subunit, pseudogene Neighboring gene predicted gene, 34213 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_09997 Neighboring gene STARR-positive B cell enhancer ABC_E11234 Neighboring gene microRNA 5123

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
    2. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
    3. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
    4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WD40 repeat-containing protein SMU1
    Names
    smu-1 suppressor of mec-8 and unc-52 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021535.4 → NP_067510.3  WD40 repeat-containing protein SMU1

      See identical proteins and their annotated locations for NP_067510.3

      Status: VALIDATED

      Source sequence(s)
      AK145982, AK163758, AK168813, BY036103
      Consensus CDS
      CCDS18050.1
      UniProtKB/Swiss-Prot
      Q3UKJ7, Q6PFR6, Q8BMY4, Q9D1I8, Q9JJ70
      Related
      ENSMUSP00000030117.5, ENSMUST00000030117.5
      Conserved Domains (5) summary
      smart00668
      Location:40 → 90
      CTLH; C-terminal to LisH motif
      COG4598
      Location:102 → 218
      HisP; ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]
      cd00200
      Location:205 → 512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:219 → 262
      7WD40; WD40 repeat [structural motif]
      pfam17814
      Location:7 → 36
      LisH_TPL; LisH-like dimerisation domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      40735649..40757885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UKJ7.2 GenPept UniProtKB/Swiss-Prot:Q3UKJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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