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    Prl3d1 prolactin family 3, subfamily d, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 18775, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Prl3d1provided by MGI
    Official Full Name
    prolactin family 3, subfamily d, member 1provided by MGI
    Primary source
    MGI:MGI:97606
    See related
    Ensembl:ENSMUSG00000057170 AllianceGenome:MGI:97606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pl1; Csh1; Ghd4; PL-I; Pl-1; PL-Ia; mPL-I; PL-I-alpha
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Is expressed in several structures, including extraembryonic component; genitourinary system; and genitourinary system mesenchyme. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 74.8) See more
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    Genomic context

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    Location:
    13 A3.1; 13 12.27 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27278172..27284243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27094189..27100260)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27a-like Neighboring gene STARR-seq mESC enhancer starr_34013 Neighboring gene STARR-seq mESC enhancer starr_34014 Neighboring gene prolactin Neighboring gene prolactin family 3, subfamily d, member 1 Neighboring gene prolactin family 3, subfamily d, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparison of the genomes of human and mouse lays the foundation of genome zoology. Emes RD, et al. Hum Mol Genet, 2003 Apr 1. PMID 12651866
    2. Trophoblast-specific transcription from the mouse placental lactogen-I gene promoter. Shida MM, et al. Mol Endocrinol, 1993 Feb. PMID 8469232
    3. Opposite effects of transforming growth factor alpha and epidermal growth factor on mouse placental lactogen I secretion. Yamaguchi M, et al. Proc Natl Acad Sci U S A, 1995 Mar 28. PMID 7535931, Free PMC Article
    4. Molecular cloning and expression of mouse placental lactogen I complementary deoxyribonucleic acid. Colosi P, et al. Mol Endocrinol, 1987 Nov. PMID 3153461
    5. Imprinted X inactivation maintained by a mouse Polycomb group gene. Wang J, et al. Nat Genet, 2001 Aug. PMID 11479595

    See all (188) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Persistent Human KIT Receptor Signaling Disposes Murine Placenta to Premature Differentiation Resulting in Severely Disrupted Placental Structure and Functionality.
      Title: Persistent Human KIT Receptor Signaling Disposes Murine Placenta to Premature Differentiation Resulting in Severely Disrupted Placental Structure and Functionality.
    2. Homozygous p21(cip) loss releases islets from growth inhibition, markedly enhancing proliferation in response to HGF and placental lactogen.
      Title: Evaluation of beta-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21cip.
    3. lactogens mediating their protective effect through the JAK2/STAT5 pathway in the beta cell and through Bcl-XL in any cell type.
      Title: Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC76481

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolactin-3D1
    Names
    chorionic somatomammotropin hormone 1
    growth hormone d4
    placental lactogen 1
    placental lactogen I
    placental lactogen-I alpha
    prolactin-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205322.1 → NP_001192251.1  prolactin-3D1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001192251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL591843
      Consensus CDS
      CCDS56874.1
      UniProtKB/Swiss-Prot
      P18121
      UniProtKB/TrEMBL
      A0A286YC78
      Related
      ENSMUSP00000152890.2, ENSMUST00000225330.2
      Conserved Domains (1) summary
      cd10288
      Location:25 → 224
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    2. NM_008864.3 → NP_032890.2  prolactin-3D1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_032890.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK082929, AL591843, CJ214787
      Consensus CDS
      CCDS88428.1
      UniProtKB/TrEMBL
      Q5SY42, Q6P244, Q8BNL4, Q8CGZ6
      Related
      ENSMUSP00000080731.5, ENSMUST00000082079.5
      Conserved Domains (1) summary
      cd10288
      Location:24 → 223
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27278172..27284243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18121.1 GenPept UniProtKB/Swiss-Prot:P18121

    Gene LinkOut

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