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    Tmem37 transmembrane protein 37 [ Mus musculus (house mouse) ]

    Gene ID: 170706, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Tmem37provided by MGI
    Official Full Name
    transmembrane protein 37provided by MGI
    Primary source
    MGI:MGI:2157899
    See related
    Ensembl:ENSMUSG00000050777 AllianceGenome:MGI:2157899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pr; Pr1
    Summary
    Predicted to enable calcium channel activity and voltage-gated ion channel activity. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in early tubule and renal interstitium. Orthologous to human TMEM37 (transmembrane protein 37). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 185.4), kidney adult (RPKM 89.5) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E2.3; 1 52.6 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (119995106..120001799, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (120067377..120074069, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene secretin receptor Neighboring gene predicted gene, 33764 Neighboring gene STARR-seq mESC enhancer starr_02045 Neighboring gene predicted gene, 41936 Neighboring gene predicted gene, 41937 Neighboring gene STARR-positive B cell enhancer ABC_E10029 Neighboring gene predicted gene, 41938

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A family of gamma-like calcium channel subunits. Klugbauer N, et al. FEBS Lett, 2000 Mar 24. PMID 10734232
    2. Calcium channel gamma subunits provide insights into the evolution of this gene family. Chu PJ, et al. Gene, 2001 Dec 12. PMID 11738816
    3. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent calcium channel gamma-like subunit
    Names
    neuronal voltage-gated calcium channel gamma-like subunit
    protein distantly related to to the gamma subunit family
    voltage-dependent calcium channel gamma subunit-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019432.3 → NP_062305.1  voltage-dependent calcium channel gamma-like subunit

      See identical proteins and their annotated locations for NP_062305.1

      Status: VALIDATED

      Source sequence(s)
      AC165443
      Consensus CDS
      CCDS15229.1
      UniProtKB/Swiss-Prot
      Q543K0, Q9JJV3
      Related
      ENSMUSP00000050862.8, ENSMUST00000056089.8
      Conserved Domains (1) summary
      pfam15108
      Location:8 → 189
      TMEM37; Voltage-dependent calcium channel gamma-like subunit protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      119995106..120001799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_878316.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJV3.1 GenPept UniProtKB/Swiss-Prot:Q9JJV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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