Mvk mevalonate kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mvkprovided by MGI
Official Full Name: mevalonate kinaseprovided by MGI
Primary source: MGI:MGI:107624
See related: Ensembl:ENSMUSG00000041939 AllianceGenome:MGI:107624
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MK; 2310010A05Rik
Summary: This gene encodes mevalonate kinase, a key enzyme involved in the biosynthesis of cholesterol and non-sterol isoprenes. The complete lack of encoded protein is lethal to mouse embryos. Mice lacking one allele of this gene exhibit increased levels of mevalonate in spleen, heart and kidney, as well as increased levels of serum immunoglobulins A and D. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression: Ubiquitous expression in adrenal adult (RPKM 27.8), stomach adult (RPKM 25.7) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5 F; 5 55.99 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (114582324..114598652)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (114444264..114460591)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analyis of the aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome
Title: Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS).
PTH stimulated BMP-2 mRNA expression via the mevalonate pathway and ROK in osteoblastic MC3T3-E1 cells
Title: Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells.
a mevalonate kinase (Mvk) allele deletion yields a murine model of hyper-IgD syndrome
Title: Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH136107 (e-PCR)
- UniSTS:210102

AI414037 (e-PCR)
- UniSTS:159426

Mvk (e-PCR), detects polymorphism
- UniSTS:507075

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mevalonate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mevalonate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables mevalonate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	ISO Inferred from Sequence Orthology more info
involved_in isoprenoid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: mevalonate kinase

NP_001293134.1

EC 2.7.1.36

NP_076045.1

EC 2.7.1.36

XP_006530246.1

EC 2.7.1.36

XP_006530248.1

EC 2.7.1.36

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001306205.2 → NP_001293134.1 mevalonate kinase isoform 1

See identical proteins and their annotated locations for NP_001293134.1

Status: REVIEWED

Source sequence(s)

AC132102

Consensus CDS

CCDS80373.1

UniProtKB/TrEMBL

Q3UEB4

Related

ENSMUSP00000107858.3, ENSMUST00000112239.9

Conserved Domains (1) summary

PLN02677
Location:10 → 389

PLN02677; mevalonate kinase
NM_001428530.1 → NP_001415459.1 mevalonate kinase isoform 1

Status: REVIEWED

Source sequence(s)

AC132102

UniProtKB/TrEMBL

Q3UEB4
NM_001428531.1 → NP_001415460.1 mevalonate kinase isoform 1

Status: REVIEWED

Source sequence(s)

AC132102

UniProtKB/Swiss-Prot

Q9R008
NM_001428532.1 → NP_001415461.1 mevalonate kinase isoform 3

Status: REVIEWED

Source sequence(s)

AC132102
NM_001428533.1 → NP_001415462.1 mevalonate kinase isoform 4

Status: REVIEWED

Source sequence(s)

AC132102
NM_001428534.1 → NP_001415463.1 mevalonate kinase isoform 4

Status: REVIEWED

Source sequence(s)

AC132102
NM_001428535.1 → NP_001415464.1 mevalonate kinase isoform 5

Status: REVIEWED

Source sequence(s)

AC132102
NM_001428536.1 → NP_001415465.1 mevalonate kinase isoform 5

Status: REVIEWED

Source sequence(s)

AC132102
NM_001428537.1 → NP_001415466.1 mevalonate kinase isoform 6

Status: REVIEWED

Source sequence(s)

AC132102

UniProtKB/TrEMBL

A0A0G2JFX8
NM_001428538.1 → NP_001415467.1 mevalonate kinase isoform 6

Status: REVIEWED

Source sequence(s)

AC132102

UniProtKB/TrEMBL

A0A0G2JFX8
NM_001428539.1 → NP_001415468.1 mevalonate kinase isoform 7

Status: REVIEWED

Source sequence(s)

AC132102

UniProtKB/TrEMBL

A0A0G2JEG0
NM_001428540.1 → NP_001415469.1 mevalonate kinase isoform 7

Status: REVIEWED

Source sequence(s)

AC132102

UniProtKB/TrEMBL

A0A0G2JEG0
NM_023556.4 → NP_076045.1 mevalonate kinase isoform 2

See identical proteins and their annotated locations for NP_076045.1

Status: REVIEWED

Source sequence(s)

AC132102

Consensus CDS

CCDS19566.1

UniProtKB/Swiss-Prot

Q9R008

Related

ENSMUSP00000036971.9, ENSMUST00000043760.15

Conserved Domains (1) summary

PLN02677
Location:10 → 377

PLN02677; mevalonate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

114582324..114598652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530183.4 → XP_006530246.1 mevalonate kinase isoform X1

Conserved Domains (1) summary

PLN02677
Location:10 → 389

PLN02677; mevalonate kinase
XM_006530185.5 → XP_006530248.1 mevalonate kinase isoform X2

Conserved Domains (1) summary

PLN02677
Location:10 → 377

PLN02677; mevalonate kinase