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    Cbr2 carbonyl reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 12409, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cbr2provided by MGI
    Official Full Name
    carbonyl reductase 2provided by MGI
    Primary source
    MGI:MGI:107200
    See related
    Ensembl:ENSMUSG00000025150 AllianceGenome:MGI:107200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MLCR
    Summary
    Enables carbonyl reductase (NADPH) activity; identical protein binding activity; and protein self-association. Predicted to be involved in glucose metabolic process and xylulose metabolic process. Predicted to act upstream of or within NADH oxidation. Located in mitochondrion. Is expressed in alimentary system; heart; nervous system; nose; and respiratory system. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 3180.6) and bladder adult (RPKM 108.6) See more
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    Genomic context

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    Location:
    11 E2; 11 84.47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120620311..120622851, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120729485..120732025, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Rac family small GTPase 3 Neighboring gene STARR-positive B cell enhancer ABC_E5314 Neighboring gene dicarbonyl L-xylulose reductase Neighboring gene high mobility group AT-hook 1B Neighboring gene NADPH-dependent carbonyl reductase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Switch of coenzyme specificity of mouse lung carbonyl reductase by substitution of threonine 38 with aspartic acid. Nakanishi M, et al. J Biol Chem, 1997 Jan 24. PMID 8999926
    2. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Tanaka N, et al. Structure, 1996 Jan 15. PMID 8805511
    3. Ultrastructural localization of carbonyl reductase in mouse lung. Matsuura K, et al. Histochem J, 1994 Apr. PMID 8040004
    4. Cloning, expression and tissue distribution of mouse tetrameric carbonyl reductase. Identity with an adipocyte 27-kDa protein. Nakanishi M, et al. Eur J Biochem, 1995 Mar 1. PMID 7705352
    5. A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation. Navre M, et al. J Cell Biol, 1988 Jul. PMID 2455724, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-xylulose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbonyl reductase (NADPH) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within NADH oxidation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xylulose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    carbonyl reductase [NADPH] 2
    Names
    AP27
    LCR
    NADPH-dependent carbonyl reductase 2
    adipocyte protein P27
    lung carbonyl reductase
    NP_031647.1
    XP_006532159.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007621.2 → NP_031647.1  carbonyl reductase [NADPH] 2

      See identical proteins and their annotated locations for NP_031647.1

      Status: VALIDATED

      Source sequence(s)
      AK081816, BF730701, BY118518
      Consensus CDS
      CCDS25756.1
      UniProtKB/Swiss-Prot
      P08074
      UniProtKB/TrEMBL
      Q542P5
      Related
      ENSMUSP00000026148.3, ENSMUST00000026148.9
      Conserved Domains (1) summary
      cd05351
      Location:1 → 244
      XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120620311..120622851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532096.2 → XP_006532159.1  carbonyl reductase [NADPH] 2 isoform X1

      UniProtKB/TrEMBL
      F6YNX9
      Related
      ENSMUSP00000117739.2, ENSMUST00000154565.2
      Conserved Domains (1) summary
      cl21454
      Location:1 → 181
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08074.1 GenPept UniProtKB/Swiss-Prot:P08074

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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