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    Cbr2 carbonyl reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 12409, updated on 25-Jan-2022

    Summary

    Official Symbol
    Cbr2provided by MGI
    Official Full Name
    carbonyl reductase 2provided by MGI
    Primary source
    MGI:MGI:107200
    See related
    Ensembl:ENSMUSG00000025150 AllianceGenome:MGI:107200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MLCR
    Summary
    Enables carbonyl reductase (NADPH) activity; identical protein binding activity; and protein self-association. Predicted to be involved in glucose metabolic process and xylulose metabolic process. Predicted to act upstream of or within NADH oxidation. Located in mitochondrion. Is expressed in alimentary system; heart; nervous system; nose; and respiratory system. [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in lung adult (RPKM 3180.6) and bladder adult (RPKM 108.6) See more
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    Genomic context

    See Cbr2 in Genome Data Viewer
    Location:
    11 E2; 11 84.47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120620311..120622851, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120729485..120732025, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120590799..120593335, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Rac family small GTPase 3 Neighboring gene dicarbonyl L-xylulose reductase Neighboring gene high mobility group AT-hook 1B Neighboring gene NADPH-dependent carbonyl reductase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-xylulose reductase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carbonyl reductase (NADPH) activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein self-association IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within NADH oxidation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in xylulose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    carbonyl reductase [NADPH] 2
    Names
    AP27
    LCR
    NADPH-dependent carbonyl reductase 2
    adipocyte protein P27
    lung carbonyl reductase
    NP_031647.1
    XP_006532159.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007621.2NP_031647.1  carbonyl reductase [NADPH] 2

      See identical proteins and their annotated locations for NP_031647.1

      Status: VALIDATED

      Source sequence(s)
      AK081816, BF730701, BY118518
      Consensus CDS
      CCDS25756.1
      UniProtKB/Swiss-Prot
      P08074
      UniProtKB/TrEMBL
      Q542P5
      Related
      ENSMUSP00000026148.3, ENSMUST00000026148.9
      Conserved Domains (1) summary
      cd05351
      Location:1244
      XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120620311..120622851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532096.2XP_006532159.1  carbonyl reductase [NADPH] 2 isoform X1

      Related
      ENSMUSP00000117739.2, ENSMUST00000154565.2
      Conserved Domains (1) summary
      cl21454
      Location:1181
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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