Prdx6 peroxiredoxin 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prdx6provided by MGI
Official Full Name: peroxiredoxin 6provided by MGI
Primary source: MGI:MGI:894320
See related: Ensembl:ENSMUSG00000026701 AllianceGenome:MGI:894320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPx; Aop2; CP-3; Ltw4; Ltw-4; NSGPx; ORF06; Prdx5; Brp-12; Lvtw-4; aiPLA2; LPCAT-5; 1-cysPrx; 1-Cys Prx; 9430088D19Rik
Summary: This gene encodes a member of the peroxiredoxin family of peroxidases. The encoded protein is a bifunctional enzyme that has glutathione peroxidase and phospholipase activities. This protein is an antioxidant that reduces peroxidized membrane phospholipids and plays an important role in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis. Mice lacking this gene are sensitive to oxidant stress, have altered lung phospholipid metabolism and susceptible to skin tumorigenesis. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Dec 2014]
Expression: Ubiquitous expression in colon adult (RPKM 178.6), lung adult (RPKM 85.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.1; 1 69.75 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (161067682..161078780, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (161240112..161251210, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.
Title: Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.
Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells.
Title: Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells.
An Increase in Peroxiredoxin 6 Expression Induces Neurotoxic A1 Astrocytes in the Lumbar Spinal Cord of Amyotrophic Lateral Sclerosis Mice Model.
Title: An Increase in Peroxiredoxin 6 Expression Induces Neurotoxic A1 Astrocytes in the Lumbar Spinal Cord of Amyotrophic Lateral Sclerosis Mice Model.
Peroxiredoxin-6 Released by Astrocytes Contributes to Neuroapoptosis During Ischemia.
Title: Peroxiredoxin-6 Released by Astrocytes Contributes to Neuroapoptosis During Ischemia.
The Role of Phospholipase Activity of Peroxiredoxin 6 in Its Transmembrane Transport and Protective Properties.
Title: The Role of Phospholipase Activity of Peroxiredoxin 6 in Its Transmembrane Transport and Protective Properties.
The role of peroxiredoxin 6 in biosynthesis of FAHFAs.
Title: The role of peroxiredoxin 6 in biosynthesis of FAHFAs.
Effect of Peroxiredoxin 6 on p53 Transcription Factor Level.
Title: Effect of Peroxiredoxin 6 on p53 Transcription Factor Level.
Prdx6-induced inhibition of ferroptosis in epithelial cells contributes to liquiritin-exerted alleviation of colitis.
Title: Prdx6-induced inhibition of ferroptosis in epithelial cells contributes to liquiritin-exerted alleviation of colitis.
PRDX6: A protein bridging S-palmitoylation and diabetic neuropathy.
Title: PRDX6: A protein bridging S-palmitoylation and diabetic neuropathy.
Peroxiredoxin 6 Modulates Insulin Secretion and Beta Cell Death via a Mitochondrial Dynamic Network.
Title: Peroxiredoxin 6 Modulates Insulin Secretion and Beta Cell Death via a Mitochondrial Dynamic Network.

Submit: New GeneRIF Correction See all GeneRIFs (86)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234248

NoName (e-PCR)
- UniSTS:234250

Prdx5 (e-PCR), detects polymorphism
- UniSTS:141091

Prdx5 (e-PCR), detects polymorphism
- UniSTS:166201

Prdx6 (e-PCR), detects polymorphism
- UniSTS:527503

RH128089 (e-PCR)
- UniSTS:211397

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peroxiredoxin activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bleb assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular oxidant detoxification	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxiredoxin-6

Names: 1-Cys peroxiredoxin; LPC acyltransferase 5; acidic calcium-independent phospholipase A2; anti-oxidant protein 2, related sequence 3; antioxidant protein 2; glutathione-dependent peroxiredoxin; lyso-PC acyltransferase 5; lysophosphatidylcholine acyltransferase 5; non-selenium glutathione peroxidase; peroxiredoxin 5, related sequence 3; peroxiredoxin 6, related sequence 3

NP_001290337.1

EC 1.11.1.27

EC 2.3.1.23

EC 3.1.1.4

NP_031479.1

EC 1.11.1.27

EC 2.3.1.23

EC 3.1.1.4

XP_030099023.1

EC 1.11.1.27

EC 2.3.1.23

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001303408.1 → NP_001290337.1 peroxiredoxin-6 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon and uses an alternate translation start site, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC115751

Consensus CDS

CCDS78724.1

UniProtKB/Swiss-Prot

O08709, Q91WT2, Q9QWP4, Q9QWW0

UniProtKB/TrEMBL

D3Z0Y2, Q53ZU7

Related

ENSMUSP00000050703.5, ENSMUST00000051925.5

Conserved Domains (1) summary

cd03016
Location:4 → 198

PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...
NM_007453.4 → NP_031479.1 peroxiredoxin-6 isoform 1

See identical proteins and their annotated locations for NP_031479.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC115751, AK030413, AK157820

Consensus CDS

CCDS15415.1

UniProtKB/Swiss-Prot

O08709, Q91WT2, Q9QWP4, Q9QWW0

UniProtKB/TrEMBL

Q53ZU7, Q6GT24

Related

ENSMUSP00000071636.6, ENSMUST00000071718.12

Conserved Domains (1) summary

cd03016
Location:7 → 222

PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

RNA

NR_130150.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks one internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). Use of an alternate translational start codon located further downstream would create an ORF that encodes a non-functional protein.

Source sequence(s)

AC115751

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

161067682..161078780 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243163.1 → XP_030099023.1 peroxiredoxin-6 isoform X1

UniProtKB/Swiss-Prot

O08709, Q91WT2, Q9QWP4, Q9QWW0

UniProtKB/TrEMBL

D3Z0Y2, Q53ZU7

Conserved Domains (1) summary

cd03016
Location:4 → 198

PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...