P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P2rx4provided by MGI
Official Full Name: purinergic receptor P2X, ligand-gated ion channel 4provided by MGI
Primary source: MGI:MGI:1338859
See related: Ensembl:ENSMUSG00000029470 AllianceGenome:MGI:1338859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2X4; D5Ertd444e
Summary: Enables extracellularly ATP-gated cation channel activity. Acts upstream of or within several processes, including excitatory postsynaptic potential; nitric oxide biosynthetic process; and vasodilation. Located in apical part of cell. Is expressed in several structures, including cardiovascular system; gut; immune system; nervous system; and viscerocranium. Orthologous to human P2RX4 (purinergic receptor P2X 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 57.8), lung adult (RPKM 28.0) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.53 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (122845581..122867802)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (122707518..122729739)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bone marrow plasma cells require P2RX4 to sense extracellular ATP.
Title: Bone marrow plasma cells require P2RX4 to sense extracellular ATP.
Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway.
Title: Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway.
P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis.
Title: P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis.
Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer's disease.
Title: Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer's disease.
Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy.
Title: Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy.
MiR-106b-5p Attenuates Neuropathic Pain by Regulating the P2X4 Receptor in the Spinal Cord in Mice.
Title: MiR-106b-5p Attenuates Neuropathic Pain by Regulating the P2X4 Receptor in the Spinal Cord in Mice.
P2X7/P2X4 Receptors Mediate Proliferation and Migration of Retinal Microglia in Experimental Glaucoma in Mice.
Title: P2X7/P2X4 Receptors Mediate Proliferation and Migration of Retinal Microglia in Experimental Glaucoma in Mice.
Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice.
Title: Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice.
Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation.
Title: Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation.
[Interference of P2X4 receptor expression in tumor-associated macrophages suppresses migration and invasion of glioma cells].
Title: [Interference of P2X4 receptor expression in tumor-associated macrophages suppresses migration and invasion of glioma cells].

Submit: New GeneRIF Correction See all GeneRIFs (72)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (7) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C86270 (e-PCR)
- UniSTS:167437

RH137366 (e-PCR)
- UniSTS:219454

AI504491 (e-PCR)
- UniSTS:159442

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP-gated ion channel activity	ISO Inferred from Sequence Orthology more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables extracellularly ATP-gated monoatomic cation channel activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables purinergic nucleotide receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to pain	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ATP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inorganic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microglial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in purinergic nucleotide receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in relaxation of cardiac muscle	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	ISO Inferred from Sequence Orthology more info
involved_in response to fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of touch	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: P2X purinoceptor 4

Names: ionotropic purinergic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310718.1 → NP_001297647.1 P2X purinoceptor 4 isoform 2

See identical proteins and their annotated locations for NP_001297647.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC115728, AK162820, BM244734, BY150918, JX417451

Consensus CDS

CCDS80392.1

UniProtKB/TrEMBL

D3Z5U5, J7IR93, Q3TR36, Q3UCX4

Related

ENSMUSP00000117193.3, ENSMUST00000142664.3

Conserved Domains (1) summary

pfam00864
Location:13 → 339

P2X_receptor; ATP P2X receptor
NM_001310720.1 → NP_001297649.1 P2X purinoceptor 4 isoform 3

See identical proteins and their annotated locations for NP_001297649.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC115728, AF089752, AK162820, BM244734, BY150918

Consensus CDS

CCDS80393.1

UniProtKB/TrEMBL

Q3TR36, Q3UCX4, Q9Z256

Related

ENSMUSP00000080269.7, ENSMUST00000081554.13

Conserved Domains (1) summary

pfam00864
Location:13 → 334

P2X_receptor; ATP P2X receptor
NM_011026.3 → NP_035156.2 P2X purinoceptor 4 isoform 1

See identical proteins and their annotated locations for NP_035156.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC115728, AF089751, AK162820, BM244734, BY150918

Consensus CDS

CCDS19654.2

UniProtKB/TrEMBL

Q3TR36, Q3UCX4, Q9Z257

Related

ENSMUSP00000031429.8, ENSMUST00000031429.14

Conserved Domains (1) summary

pfam00864
Location:13 → 361

P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

122845581..122867802

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530196.4 → XP_006530259.1 P2X purinoceptor 4 isoform X1

UniProtKB/TrEMBL

D3YYR5, Q3TR36, Q3UCX4

Related

ENSMUSP00000118163.3, ENSMUST00000139631.8

Conserved Domains (1) summary

cl02993
Location:1 → 312

P2X_receptor; ATP P2X receptor
XM_036164869.1 → XP_036020762.1 P2X purinoceptor 4 isoform X2

Conserved Domains (1) summary

pfam00864
Location:1 → 233

P2X_receptor; ATP P2X receptor