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    Ubxn4 UBX domain protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 67812, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ubxn4provided by MGI
    Official Full Name
    UBX domain protein 4provided by MGI
    Primary source
    MGI:MGI:1915062
    See related
    Ensembl:ENSMUSG00000026353 AllianceGenome:MGI:1915062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubxd2; mKIAA0242; 1300013G12Rik
    Summary
    Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in cytosol and endoplasmic reticulum. Is expressed in embryo. Orthologous to human UBXN4 (UBX domain protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 17.2), CNS E14 (RPKM 13.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E3; 1 55.8 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (128171635..128207115)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (128243898..128279378)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene male-enhanced antigen 1 pseudogene Neighboring gene R3H domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02158 Neighboring gene microRNA 128-1 Neighboring gene STARR-seq mESC enhancer starr_02159 Neighboring gene STARR-positive B cell enhancer ABC_E9060 Neighboring gene predicted gene, 41949 Neighboring gene lactase Neighboring gene STARR-positive B cell enhancer ABC_E7743 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130255918-130256027 Neighboring gene STARR-positive B cell enhancer ABC_E2006 Neighboring gene minichromosome maintenance complex component 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle. Aweida D, et al. EMBO Rep, 2022 Dec 6. PMID 36278411, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0242

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UBX domain-containing protein 4
    Names
    UBX domain containing 2
    UBX domain-containing protein 2
    erasin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356529.1 → NP_001343458.1  UBX domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161809
      UniProtKB/Swiss-Prot
      Q3UGR4, Q8BW17, Q8VCH8
      Conserved Domains (2) summary
      smart00166
      Location:319 → 394
      UBX; Domain present in ubiquitin-regulatory proteins
      cl00388
      Location:4 → 113
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. NM_026390.3 → NP_080666.2  UBX domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_080666.2

      Status: VALIDATED

      Source sequence(s)
      AC161809, AK029431, AK075716, AK147795, AK148889, BQ745792
      Consensus CDS
      CCDS15251.1
      UniProtKB/Swiss-Prot
      Q3UGR4, Q8BW17, Q8VCH8
      UniProtKB/TrEMBL
      A0A0R4J078
      Related
      ENSMUSP00000027592.4, ENSMUST00000027592.6
      Conserved Domains (2) summary
      smart00166
      Location:318 → 393
      UBX; Domain present in ubiquitin-regulatory proteins
      cl00388
      Location:4 → 113
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      128171635..128207115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529831.2 → XP_006529894.1  UBX domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q3UGR4, Q8BW17, Q8VCH8
      Conserved Domains (2) summary
      cl00388
      Location:4 → 113
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl28922
      Location:318 → 355
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_017322239.1 → XP_017177728.1  UBX domain-containing protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q3UGR4, Q8BW17, Q8VCH8
      Conserved Domains (2) summary
      cl00388
      Location:4 → 113
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl28922
      Location:317 → 354
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCH8.1 GenPept UniProtKB/Swiss-Prot:Q8VCH8

    Gene LinkOut

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