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    Ypel3 yippee like 3 [ Mus musculus (house mouse) ]

    Gene ID: 66090, updated on 14-May-2024

    Summary

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    Official Symbol
    Ypel3provided by MGI
    Official Full Name
    yippee like 3provided by MGI
    Primary source
    MGI:MGI:1913340
    See related
    Ensembl:ENSMUSG00000042675 AllianceGenome:MGI:1913340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Suap; 0610043B10Rik; 1190001G19Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of cellular senescence. Predicted to act upstream of or within apoptotic process. Predicted to be located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system gland; nervous system; and reproductive system. Orthologous to human YPEL3 (yippee like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 190.6), mammary gland adult (RPKM 124.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ypel3 in Genome Data Viewer
    Location:
    7 F3; 7 69.25 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126376135..126379682)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126776963..126780510)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 3 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E6602 Neighboring gene T-box 6 Neighboring gene protein phosphatase 4, catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E6603

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Small unstable apoptotic protein, an apoptosis-associated protein, suppresses proliferation of myeloid cells. Baker SJ. Cancer Res, 2003 Feb 1. PMID 12566317
    2. Why YPEL3 represents a novel tumor suppressor. Berberich SJ, et al. Front Biosci (Landmark Ed), 2011 Jan 1. PMID 21196260
    3. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
    4. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. Hosono K, et al. Genomics, 2010 Aug. PMID 20580816
    5. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. Ishimura A, et al. Cell Tissue Res, 2016 Mar. PMID 26334721

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein yippee-like 3
    Names
    small ubiquitinated apoptotic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379293.1 → NP_001366222.1  protein yippee-like 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AC124505
      UniProtKB/Swiss-Prot
      P61237, Q71E85, Q9D0U3
      UniProtKB/TrEMBL
      D3YZG6
      Conserved Domains (1) summary
      cl13152
      Location:21 → 110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    2. NM_001379294.1 → NP_001366223.1  protein yippee-like 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 1-3 and 5, encodes the longer isoform (a).
      Source sequence(s)
      AC124505
      UniProtKB/Swiss-Prot
      P61237, Q71E85, Q9D0U3
      UniProtKB/TrEMBL
      D3YZG6
      Conserved Domains (1) summary
      cl13152
      Location:21 → 110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    3. NM_001379295.1 → NP_001366224.1  protein yippee-like 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1-4, encodes the longer isoform (a).
      Source sequence(s)
      AC124505
      UniProtKB/Swiss-Prot
      P61237, Q71E85, Q9D0U3
      UniProtKB/TrEMBL
      D3YZG6
      Related
      ENSMUSP00000101963.2, ENSMUST00000106356.2
      Conserved Domains (1) summary
      cl13152
      Location:21 → 110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    4. NM_001379296.1 → NP_001366225.1  protein yippee-like 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform b.
      Source sequence(s)
      AC124505
      Conserved Domains (1) summary
      cl13152
      Location:48 → 81
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    5. NM_001379297.1 → NP_001366226.1  protein yippee-like 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 6, encodes isoform b.
      Source sequence(s)
      AC124505
      Conserved Domains (1) summary
      cl13152
      Location:48 → 81
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    6. NM_025347.3 → NP_079623.1  protein yippee-like 3 isoform a

      See identical proteins and their annotated locations for NP_079623.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3-5, encodes the longer isoform (a).
      Source sequence(s)
      AC124505
      Consensus CDS
      CCDS21842.1
      UniProtKB/Swiss-Prot
      P61237, Q71E85, Q9D0U3
      UniProtKB/TrEMBL
      D3YZG6
      Related
      ENSMUSP00000037332.6, ENSMUST00000038614.12
      Conserved Domains (1) summary
      cl13152
      Location:21 → 110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    7. NM_026875.3 → NP_081151.2  protein yippee-like 3 isoform a

      See identical proteins and their annotated locations for NP_081151.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variants 2-5, encodes the longer isoform (a).
      Source sequence(s)
      AC124505
      Consensus CDS
      CCDS21842.1
      UniProtKB/Swiss-Prot
      P61237, Q71E85, Q9D0U3
      UniProtKB/TrEMBL
      D3YZG6
      Related
      ENSMUSP00000128753.2, ENSMUST00000170882.8
      Conserved Domains (1) summary
      cl13152
      Location:21 → 110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126376135..126379682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61237.1 GenPept UniProtKB/Swiss-Prot:P61237

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