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    Gucd1 guanylyl cyclase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 68778, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gucd1provided by MGI
    Official Full Name
    guanylyl cyclase domain containing 1provided by MGI
    Primary source
    MGI:MGI:1916028
    See related
    Ensembl:ENSMUSG00000033416 AllianceGenome:MGI:1916028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110038D17Rik
    Summary
    Is expressed in liver lobe and metanephros. Orthologous to human GUCD1 (guanylyl cyclase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 37.8), duodenum adult (RPKM 36.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 38.53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75342648..75353806, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75506814..75517972, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ureidopropionase, beta Neighboring gene STARR-positive B cell enhancer ABC_E9345 Neighboring gene RIKEN cDNA 4933407G14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6873 Neighboring gene STARR-positive B cell enhancer ABC_E9793 Neighboring gene small nuclear ribonucleoprotein D3 Neighboring gene predicted gene, 35061 Neighboring gene leucine rich repeat containing 75B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Endoh-Yamagami S, et al. Dev Biol, 2010 Apr 1. PMID 20096683
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein GUCD1
    Names
    guanylyl cyclase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347201.1 → NP_001334130.1  protein GUCD1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC144461, AK034509, BE952992
      Consensus CDS
      CCDS83713.1
      UniProtKB/TrEMBL
      A0A0R4J1X3, Q05CJ4
      Related
      ENSMUSP00000113976.2, ENSMUST00000118936.8
      Conserved Domains (1) summary
      pfam09778
      Location:1 → 196
      Guanylate_cyc_2; Guanylylate cyclase

    2. NM_175133.2 → NP_780342.1  protein GUCD1 isoform 1

      See identical proteins and their annotated locations for NP_780342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC144461, AK034509, AK040832, BE952992
      Consensus CDS
      CCDS35936.1
      UniProtKB/Swiss-Prot
      Q147V8, Q3TZX7, Q80XN8, Q8BLZ0, Q8BZI6
      UniProtKB/TrEMBL
      A0A0R4J1X3
      Related
      ENSMUSP00000043000.8, ENSMUST00000039796.14
      Conserved Domains (1) summary
      pfam09778
      Location:22 → 235
      Guanylate_cyc_2; Guanylylate cyclase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75342648..75353806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514034.4 → XP_006514097.2  protein GUCD1 isoform X1

      UniProtKB/TrEMBL
      A0A0R4J1X3, Q05CJ4
      Conserved Domains (1) summary
      pfam09778
      Location:1 → 196
      Guanylate_cyc_2; Guanylylate cyclase

    2. XM_030245248.2 → XP_030101108.1  protein GUCD1 isoform X2

      Conserved Domains (1) summary
      pfam09778
      Location:1 → 161
      Guanylate_cyc_2; Guanylylate cyclase

    3. XM_036155978.1 → XP_036011871.1  protein GUCD1 isoform X2

      Conserved Domains (1) summary
      pfam09778
      Location:1 → 161
      Guanylate_cyc_2; Guanylylate cyclase

    4. XM_030245249.2 → XP_030101109.1  protein GUCD1 isoform X2

      Conserved Domains (1) summary
      pfam09778
      Location:1 → 161
      Guanylate_cyc_2; Guanylylate cyclase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZI6.2 GenPept UniProtKB/Swiss-Prot:Q8BZI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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