Nap1l1 nucleosome assembly protein 1-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nap1l1provided by MGI
Official Full Name: nucleosome assembly protein 1-like 1provided by MGI
Primary source: MGI:MGI:1855693
See related: Ensembl:ENSMUSG00000058799 AllianceGenome:MGI:1855693
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NAP-1; D10Ertd68e
Summary: Predicted to enable chromatin binding activity; histone binding activity; and kinase binding activity. Involved in positive regulation of neural precursor cell proliferation and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in forebrain ventricular layer; ganglionic eminence; metanephros; and nucleus pulposus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human NAP1L1 (nucleosome assembly protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 94.0), CNS E14 (RPKM 38.5) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 58.67 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (111308754..111334011)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (111472882..111498150)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NAP1L1 promotes the growth of colon cancer by activating HDGF/DDX5.
Title: NAP1L1 promotes the growth of colon cancer by activating HDGF/DDX5.
NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
Title: NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
These findings reveal an essential role for the Nap1l1 histone chaperone in cortical neurogenesis during early embryonic brain development.
Title: Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain.
Nap1l1 promotes the proliferation of iPSC attributable to G2/M transition caused by downregulation of p27 and p21, and upregulation of cyclin B1, the activation of AKT or ERK is involved in the process.
Title: Nucleosome Assembly Protein 1-Like 1 (Nap1l1) Regulates the Proliferation of Murine Induced Pluripotent Stem Cells.
The molecular interaction between DGKzeta and Nap1l1 was attenuated after hypoxic stress.
Title: Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress.
Downregulation of Nap1l1 significantly enhances mesodermal induction and subsequent cardiogenesis of murine induced pluripotent stem cells via inhibition of gamma-secretase-regulated Notch signaling.
Title: Knockdown of nucleosome assembly protein 1-like 1 induces mesoderm formation and cardiomyogenesis via notch signaling in murine-induced pluripotent stem cells.
Nap1l1 is a novel protein that regulates cardiomyocytes differentiation of P19CL6 cells induced by dimethyl sulfoxide.
Title: Knockdown of nucleosome assembly protein 1-like 1 promotes dimethyl sulfoxide-induced differentiation of P19CL6 cells into cardiomyocytes.
Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4.
Title: Interaction between nucleosome assembly protein 1-like family members.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14S655E (e-PCR)
- UniSTS:151553

px-31f3 (e-PCR)
- UniSTS:257585

RH126750 (e-PCR)
- UniSTS:167009

RH124568 (e-PCR)
- UniSTS:161390

D10Ertd68e (e-PCR), detects polymorphism
- UniSTS:167029

RH136078 (e-PCR)
- UniSTS:210073

px-38e3 (e-PCR)
- UniSTS:257695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone chaperone activity	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleosome assembly protein 1-like 1

Names: NAP-1-related protein; brain protein DN38; nucleosome assembly protein-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358932.1 → NP_001345861.1 nucleosome assembly protein 1-like 1 isoform 3

Status: VALIDATED

Source sequence(s)

AK011301, AK012250, AW488539, BF458793, BM948894, BY253657

UniProtKB/TrEMBL

Q9CSP8

Conserved Domains (1) summary

pfam00956
Location:15 → 280

NAP; Nucleosome assembly protein (NAP)
NM_001428957.1 → NP_001415886.1 nucleosome assembly protein 1-like 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC166253
NM_001428958.1 → NP_001415887.1 nucleosome assembly protein 1-like 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC166253
NM_001428959.1 → NP_001415888.1 nucleosome assembly protein 1-like 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC166253
NM_001428960.1 → NP_001415889.1 nucleosome assembly protein 1-like 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC166253
NM_001428961.1 → NP_001415890.1 nucleosome assembly protein 1-like 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC166253
NM_015781.5 → NP_056596.1 nucleosome assembly protein 1-like 1 isoform 2

See identical proteins and their annotated locations for NP_056596.1

Status: VALIDATED

Source sequence(s)

AK011301, AK136161, BF458793

Consensus CDS

CCDS36058.1

UniProtKB/Swiss-Prot

P28656, Q3UL14

UniProtKB/TrEMBL

Q3TF41

Related

ENSMUSP00000070068.9, ENSMUST00000065917.16

Conserved Domains (1) summary

pfam00956
Location:78 → 343

NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

111308754..111334011

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245178.2 → XP_030101038.1 nucleosome assembly protein 1-like 1 isoform X1

UniProtKB/Swiss-Prot

P28656, Q3UL14

UniProtKB/TrEMBL

Q3TF41

Related

ENSMUSP00000151750.2, ENSMUST00000217908.2

Conserved Domains (1) summary

pfam00956
Location:78 → 343

NAP; Nucleosome assembly protein (NAP)
XM_030245179.1 → XP_030101039.1 nucleosome assembly protein 1-like 1 isoform X3

UniProtKB/TrEMBL

Q9CSP8

Conserved Domains (1) summary

pfam00956
Location:15 → 280

NAP; Nucleosome assembly protein (NAP)
XM_036155892.1 → XP_036011785.1 nucleosome assembly protein 1-like 1 isoform X2

UniProtKB/TrEMBL

Q9CSP8

Conserved Domains (1) summary

pfam00956
Location:35 → 302

NAP; Nucleosome assembly protein (NAP)

RNA

XR_001779558.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001146707.1: Suppressed sequence

Description

NM_001146707.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
NR_152558.1: Suppressed sequence

Description

NR_152558.1: This RefSeq was removed because currently there is insufficient support for the transcript.