Higd1a HIG1 domain family, member 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Higd1aprovided by MGI
Official Full Name: HIG1 domain family, member 1Aprovided by MGI
Primary source: MGI:MGI:1930666
See related: Ensembl:ENSMUSG00000038412 AllianceGenome:MGI:1930666
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hig1; HIMP1; 2210020B17Rik; 7420700H20Rik
Summary: Acts upstream of or within several processes, including cellular response to glucose starvation; negative regulation of release of cytochrome c from mitochondria; and positive regulation of protein serine/threonine kinase activity. Located in mitochondrial inner membrane and nucleus. Orthologous to human HIGD1A (HIG1 hypoxia inducible domain family member 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 19.8), frontal lobe adult (RPKM 17.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 72.67 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (121677623..121686862, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (121848557..121857796, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway.
Title: HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway.
Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-kappaB-NR2F1 nexus.
Title: Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-κB-NR2F1 nexus.
Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice.
Title: Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice.
Higd1a plays positive roles in protecting cells from oxidative stress, and reactive oxygen species could induce Higd1a expression by upregulating PGC-1a and HIF-1a expressions.
Title: Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure.
Important role in stress protective programs in mitochondria.
Title: Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW049839 (e-PCR)
- UniSTS:164430

AI303276 (e-PCR)
- UniSTS:159940

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to glucose starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial respirasome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in respirasome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: HIG1 domain family member 1A, mitochondrial

Names: hypoxia induced gene 1; hypoxia-inducible gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357837.1 → NP_001344766.1 HIG1 domain family member 1A, mitochondrial

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.

Source sequence(s)

AC165080, AI303276, AK018360, BE457620, CJ042199

Consensus CDS

CCDS40812.1

UniProtKB/Swiss-Prot

Q9JLR9

UniProtKB/TrEMBL

A0A1L1ST61, Q1XG81

Conserved Domains (1) summary

pfam04588
Location:28 → 76

HIG_1_N; Hypoxia induced protein conserved region
NM_001357838.1 → NP_001344767.1 HIG1 domain family member 1A, mitochondrial

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

AA414831, AI303276, AK018360, BE457620

Consensus CDS

CCDS40812.1

UniProtKB/Swiss-Prot

Q9JLR9

UniProtKB/TrEMBL

A0A1L1ST61, Q1XG81

Related

ENSMUSP00000149531.2, ENSMUST00000213124.2

Conserved Domains (1) summary

pfam04588
Location:28 → 76

HIG_1_N; Hypoxia induced protein conserved region
NM_001357839.1 → NP_001344768.1 HIG1 domain family member 1A, mitochondrial

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

AI303276, AK018360, BE457620, CJ042267

Consensus CDS

CCDS40812.1

UniProtKB/Swiss-Prot

Q9JLR9

UniProtKB/TrEMBL

A0A1L1ST61, Q1XG81

Conserved Domains (1) summary

pfam04588
Location:28 → 76

HIG_1_N; Hypoxia induced protein conserved region
NM_001357840.1 → NP_001344769.1 HIG1 domain family member 1A, mitochondrial

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

AI303276, AK018360, BE457620, BE689839

Consensus CDS

CCDS40812.1

UniProtKB/Swiss-Prot

Q9JLR9

UniProtKB/TrEMBL

A0A1L1ST61, Q1XG81

Related

ENSMUSP00000150726.2, ENSMUST00000215300.2

Conserved Domains (1) summary

pfam04588
Location:28 → 76

HIG_1_N; Hypoxia induced protein conserved region
NM_001357841.1 → NP_001344770.1 HIG1 domain family member 1A, mitochondrial

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

AI303276, AK018360, BE457620, BU851504

Consensus CDS

CCDS40812.1

UniProtKB/Swiss-Prot

Q9JLR9

UniProtKB/TrEMBL

A0A1L1ST61, Q1XG81

Conserved Domains (1) summary

pfam04588
Location:28 → 76

HIG_1_N; Hypoxia induced protein conserved region
NM_019814.5 → NP_062788.1 HIG1 domain family member 1A, mitochondrial

See identical proteins and their annotated locations for NP_062788.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.

Source sequence(s)

AI303276, AK018360, BE457620

Consensus CDS

CCDS40812.1

UniProtKB/Swiss-Prot

Q9JLR9

UniProtKB/TrEMBL

A0A1L1ST61, Q1XG81

Related

ENSMUSP00000054881.7, ENSMUST00000060251.8

Conserved Domains (1) summary

pfam04588
Location:28 → 76

HIG_1_N; Hypoxia induced protein conserved region