Tbrg1 transforming growth factor beta regulated gene 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbrg1provided by MGI
Official Full Name: transforming growth factor beta regulated gene 1provided by MGI
Primary source: MGI:MGI:1100877
See related: Ensembl:ENSMUSG00000011114 AllianceGenome:MGI:1100877
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Niam; Tb-5; mFLJ00213
Summary: Predicted to be involved in several processes, including DNA replication; protein localization to nucleoplasm; and protein stabilization. Predicted to be located in nucleoplasm. Is expressed in several structures, including cranium; genitourinary system; jaw; liver; and spleen. Orthologous to human TBRG1 (transforming growth factor beta regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 174.8), testis adult (RPKM 45.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.79 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (37560478..37568608, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (37649182..37657312, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data provides a useful resource for exploring Myst2 and Niam essential cellular functions and should contribute to deeper understanding of organism early development and survival as well as cancer.
Title: Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells.
NIAM down-regulation in vivo results in a significant predisposition to developing benign tumors or early stage cancers.
Title: NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas.
novel protein with tumor suppressor-like behaviors and functional links to ARF-MDM2-p53 signaling
Title: A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125865 (e-PCR)
- UniSTS:162601

RH125806 (e-PCR)
- UniSTS:162552

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein localization to nucleoplasm	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: transforming growth factor beta regulator 1

Names: nuclear interactor of ARF and Mdm2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.