Pttg1 pituitary tumor-transforming gene 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pttg1provided by MGI
Official Full Name: pituitary tumor-transforming gene 1provided by MGI
Primary source: MGI:MGI:1353578
See related: Ensembl:ENSMUSG00000020415 AllianceGenome:MGI:1353578
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pttg; Pttg3
Summary: Enables cysteine-type endopeptidase inhibitor activity. Acts upstream of or within homologous chromosome segregation and mitotic sister chromatid cohesion. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; limb; mesonephric tubule of male; and testis. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 18.7), testis adult (RPKM 15.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.1; 11 25.68 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (43311097..43317417, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (43420244..43427463, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression.
Title: PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression.
PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.
Title: PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis.
The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
Title: The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells.
Title: Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells.
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.
Title: A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.
The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.
Title: The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.
The findings show that maternal aging compromises the oocyte SAC-APC/C axis leading to a decrease in securin that ultimately causes sister chromatid cohesion loss.
Title: Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.
Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.
Title: Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition.
High PTTG1 expression is associated with pituitary tumor development.
Title: mTOR promotes pituitary tumor development through activation of PTTG1.
PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.
Title: Pituitary tumor transforming gene as a novel regulatory factor of liver fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW555095 (e-PCR)
- UniSTS:180177

C87862 (e-PCR)
- UniSTS:209370

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in homologous chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homologous chromosome segregation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mitotic sister chromatid cohesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: securin

Names: pituitary tumor-transforming 1; pituitary tumor-transforming gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131054.3 → NP_001124526.1 securin isoform 1

See identical proteins and their annotated locations for NP_001124526.1

Status: VALIDATED

Source sequence(s)

AL670472

Consensus CDS

CCDS48771.1

UniProtKB/Swiss-Prot

O88887, Q9CQJ7, Q9Z2E6

UniProtKB/TrEMBL

Q3Y5K4

Related

ENSMUSP00000020687.9, ENSMUST00000020687.15

Conserved Domains (1) summary

pfam04856
Location:1 → 188

Securin; Securin sister-chromatid separation inhibitor
NM_001362799.2 → NP_001349728.1 securin isoform 1

Status: VALIDATED

Source sequence(s)

AL670472

Consensus CDS

CCDS48771.1

UniProtKB/Swiss-Prot

O88887, Q9CQJ7, Q9Z2E6

UniProtKB/TrEMBL

Q3Y5K4

Related

ENSMUSP00000098894.5, ENSMUST00000101340.11

Conserved Domains (1) summary

pfam04856
Location:1 → 188

Securin; Securin sister-chromatid separation inhibitor
NM_001425538.1 → NP_001412467.1 securin isoform 1

Status: VALIDATED

Source sequence(s)

AL670472

UniProtKB/Swiss-Prot

O88887, Q9CQJ7, Q9Z2E6
NM_001425539.1 → NP_001412468.1 securin isoform 1

Status: VALIDATED

Source sequence(s)

AL670472

UniProtKB/Swiss-Prot

O88887, Q9CQJ7, Q9Z2E6
NM_001425540.1 → NP_001412469.1 securin isoform 1

Status: VALIDATED

Source sequence(s)

AL670472

UniProtKB/Swiss-Prot

O88887, Q9CQJ7, Q9Z2E6
NM_001425541.1 → NP_001412470.1 securin isoform 1

Status: VALIDATED

Source sequence(s)

AL670472

UniProtKB/Swiss-Prot

O88887, Q9CQJ7, Q9Z2E6
NM_001425542.1 → NP_001412471.1 securin isoform 3

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425543.1 → NP_001412472.1 securin isoform 3

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425544.1 → NP_001412473.1 securin isoform 2

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425545.1 → NP_001412474.1 securin isoform 2

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425546.1 → NP_001412475.1 securin isoform 2

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425547.1 → NP_001412476.1 securin isoform 2

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425548.1 → NP_001412477.1 securin isoform 2

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425549.1 → NP_001412478.1 securin isoform 2

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425550.1 → NP_001412479.1 securin isoform 2

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425551.1 → NP_001412480.1 securin isoform 4

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425552.1 → NP_001412481.1 securin isoform 4

Status: VALIDATED

Source sequence(s)

AL670472
NM_001425553.1 → NP_001412482.1 securin isoform 4

Status: VALIDATED

Source sequence(s)

AL670472
NM_013917.4 → NP_038945.2 securin isoform 2

See identical proteins and their annotated locations for NP_038945.2

Status: VALIDATED

Source sequence(s)

AL670472

Consensus CDS

CCDS24556.1

UniProtKB/TrEMBL

Q3Y5K4

Related

ENSMUSP00000112841.2, ENSMUST00000117446.8

Conserved Domains (1) summary

pfam04856
Location:1 → 173

Securin; Securin sister-chromatid separation inhibitor