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    Cd99 CD99 molecule (Xg blood group) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 652929, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cd99provided by RGD
    Official Full Name
    CD99 molecule (Xg blood group)provided by RGD
    Primary source
    RGD:1594332
    See related
    AllianceGenome:RGD:1594332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in T cell extravasation; homotypic cell-cell adhesion; and positive regulation of neutrophil extravasation. Predicted to act upstream of or within myeloid dendritic cell activation. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Orthologous to human CD99 (CD99 molecule (Xg blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 301.4), Kidney (RPKM 234.9) and 9 other tissues See more
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    Genomic context

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    Location:
    20q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (56000494..56005140, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (54418239..54422882, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (56192426..56196961, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556677 Neighboring gene uncharacterized LOC103694460 Neighboring gene dehydrogenase/reductase X-linked like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rapid divergency of rodent CD99 orthologs: implications for the evolution of the pseudoautosomal region. Park SH, et al. Gene, 2005 Jul 4. PMID 15978751
    2. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. Shiratori I, et al. J Exp Med, 2004 Feb 16. PMID 14970179, Free PMC Article
    3. A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo. Bixel MG, et al. Blood, 2007 Jun 15. PMID 17344467
    4. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in T cell extravasation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within T cell extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homotypic cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myeloid dendritic cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neutrophil extravasation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of neutrophil extravasation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CD99 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100804.1 → NP_001094274.1  CD99 antigen precursor

      See identical proteins and their annotated locations for NP_001094274.1

      Status: VALIDATED

      Source sequence(s)
      AY262357, BC168196
      UniProtKB/TrEMBL
      B4F7A5, Q4L2A2
      Conserved Domains (1) summary
      pfam12301
      Location:52 → 163
      CD99L2; CD99 antigen like protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      56000494..56005140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099057.2 → XP_038954985.1  CD99 antigen isoform X3

      Conserved Domains (1) summary
      pfam12301
      Location:25 → 134
      CD99L2; CD99 antigen like protein 2

    2. XM_039099056.2 → XP_038954984.1  CD99 antigen isoform X2

      UniProtKB/TrEMBL
      A6K6T0, Q4L2A2

    3. XM_063279500.1 → XP_063135570.1  CD99 antigen isoform X1

    4. XM_063279502.1 → XP_063135572.1  CD99 antigen isoform X5

    5. XM_063279501.1 → XP_063135571.1  CD99 antigen isoform X4

      UniProtKB/TrEMBL
      A6K6T1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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