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    ISR1 putative protein kinase ISR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856221, updated on 13-Apr-2024

    Summary

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    Gene symbol
    ISR1
    Gene description
    putative protein kinase ISR1
    Primary source
    SGD:S000006310
    Locus tag
    YPR106W
    See related
    AllianceGenome:SGD:S000006310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein kinase activity. Involved in negative regulation of UDP-N-acetylglucosamine biosynthetic process; peptidyl-serine phosphorylation; and peptidyl-threonine phosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (740061..741392)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Fhl1p Neighboring gene Golgi transport complex subunit COG4 Neighboring gene cleavage polyadenylation factor RNA-binding subunit YTH1 Neighboring gene proteasome regulatory particle lid subunit RPN7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional interaction of Isr1, a predicted protein kinase, with the Pkc1 pathway in Saccharomyces cerevisiae. Miyahara K, et al. Biosci Biotechnol Biochem, 1998 Jul. PMID 9720220
    2. Redundant targeting of Isr1 by two CDKs in mitotic cells. Alme EB, et al. Curr Genet, 2021 Feb. PMID 33063175, Free PMC Article
    3. Dosage suppression of the Kluyveromyces lactis zymocin by Saccharomyces cerevisiae ISR1 and UGP1. Mehlgarten C, et al. FEMS Yeast Res, 2007 Aug. PMID 17367514
    4. The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae. Alme EB, et al. PLoS Genet, 2020 Jun. PMID 32579556, Free PMC Article
    5. Combining chemical genetics and proteomics to identify protein kinase substrates. Dephoure N, et al. Proc Natl Acad Sci U S A, 2005 Dec 13. PMID 16330754, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Redundant targeting of Isr1 by two CDKs in mitotic cells.
      Title: Redundant targeting of Isr1 by two CDKs in mitotic cells.
    2. The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae.
      Title: The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae.
    3. In sum, high-copy ISR1 and UGP1 cells affect early steps of the zymocin response and potentially prevent the lethal K. lactis killer complex from establishing cell surface recognition and/or contact.
      Title: Dosage suppression of the Kluyveromyces lactis zymocin by Saccharomyces cerevisiae ISR1 and UGP1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of UDP-N-acetylglucosamine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of UDP-N-acetylglucosamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic translational initiation in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translational initiation by eIF2 alpha phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative protein kinase ISR1
    NP_015431.1
    • Predicted protein kinase; negatively regulates the hexosamine biosynthetic pathway (HBP), which converts fructose-6-phosphate into UDP-N-acetylglucosamine, a precursor of chitin biosynthesis, GPI-anchor formation and glycosylation; interacts genetically with GFA1, encoding the first enzyme in the HBP; involved in Gfa1p phosphorylation (S332, T334); contains a Pho85p-regulated SCF-CDC4 phosphodegron; unstable, cell cycle regulated protein, peaking at G1/S

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      740061..741392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184203.1 → NP_015431.1  TPA: putative protein kinase ISR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015431.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4A4, Q06098
      UniProtKB/TrEMBL
      A0A6A5Q1L8, A6ZWY6, B5VTP6, C7GXR7, N1NWF6
      Conserved Domains (1) summary
      cl21453
      Location:142 → 372
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06098.1

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