Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gga2provided by MGI
Official Full Name: golgi associated, gamma adaptin ear containing, ARF binding protein 2provided by MGI
Primary source: MGI:MGI:1921355
See related: Ensembl:ENSMUSG00000030872 AllianceGenome:MGI:1921355
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1080; 1200007E24Rik
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane protein transport and protein localization to cell surface. Predicted to act upstream of or within protein transport. Predicted to be located in clathrin-coated vesicle and trans-Golgi network. Is expressed in several structures, including branchial arch; heart; liver; lung; and white fat. Orthologous to human GGA2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 61.9), limb E14.5 (RPKM 23.5) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 65.21 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (121585945..121620421, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (121986722..122021198, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GGA2 binds to the internal DXXLL motif of the LRP9
Title: Do GGA adaptors bind internal DXXLL motifs?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell surface	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor-binding protein GGA2

Names: gamma-adaptin-related protein 2; golgi-localized, gamma ear-containing, ARF-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028758.2 → NP_083034.1 ADP-ribosylation factor-binding protein GGA2

See identical proteins and their annotated locations for NP_083034.1

Status: VALIDATED

Source sequence(s)

AC126941, AK143691, BY291970

Consensus CDS

CCDS40116.1

UniProtKB/Swiss-Prot

Q3U374, Q6P5E6, Q6PFX3, Q6ZPY8, Q8BM76, Q9DC15

UniProtKB/TrEMBL

Q3TVV9, Q3UE19

Related

ENSMUSP00000033160.9, ENSMUST00000033160.15

Conserved Domains (4) summary

smart00809
Location:481 → 595

Alpha_adaptinC2; Adaptin C-terminal domain

cd17010
Location:29 → 166

VHS_GGA2; VHS (Vps27/Hrs/STAM) domain of ADP-ribosylation factor-binding protein GGA2

pfam18308
Location:187 → 226

GGA_N-GAT; GGA N-GAT domain

cl03906
Location:229 → 317

GAT_SF; GAT domain found in eukaryotic ADP-ribosylation factor (Arf)-binding proteins (GGAs), metazoan myb protein 1 (Tom1)-like proteins, and similar proteins