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    TwdlT TweedleT [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44790, updated on 10-May-2024

    Summary

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    Official Symbol
    TwdlTprovided by FlyBase
    Official Full Name
    TweedleTprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029170
    Locus tag
    Dmel_CG5812
    See related
    AllianceGenome:FB:FBgn0029170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5812; Dmel\CG5812; GCR(ich)
    Summary
    Predicted to be a structural constituent of chitin-based cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Is expressed in several structures, including embryonic head epidermis; embryonic/larval posterior spiracle; foregut; lateral cord neurons; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See TwdlT in Genome Data Viewer
    Location:
    97D14-97D14; 3-92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27049220..27051004)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22874942..22876726)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RYamide receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Neprilysin 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spatzle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
    2. Transcriptional changes revealed genes and pathways involved in the deficient testis caused by the inhibition of alkaline ceramidase (Dacer) in Drosophila melanogaster. Zhang MJ, et al. Arch Insect Biochem Physiol, 2021 Mar. PMID 33590535
    3. The distribution of GYR- and YLP-like motifs in Drosophila suggests a general role in cuticle assembly and other protein-protein interactions. Cornman RS. PLoS One, 2010 Sep 2. PMID 20824096, Free PMC Article
    4. Transcriptomic Insights into the Insect Immune Response to Nematode Infection. Eleftherianos I, et al. Genes (Basel), 2021 Jan 30. PMID 33573306, Free PMC Article
    5. Identification and functional analysis of healing regulators in Drosophila. Álvarez-Fernández C, et al. PLoS Genet, 2015. PMID 25647511, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in body morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chitin-based cuticle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TweedleT
    Names
    CG5812-PA
    GCR(ich)
    TwdlT-PA
    tweedle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27049220..27051004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143742.3 → NP_651999.1  TweedleT [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651999.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1G9, Q9VB86
      Related
      FBpp0084471
      Conserved Domains (1) summary
      pfam03103
      Location:132 → 225
      DUF243; Domain of unknown function (DUF243)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U1G9 Q9U1G9
    Q9VB86 Q9VB86

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