Bcl2l2 Bcl2-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bcl2l2provided by RGD
Official Full Name: Bcl2-like 2provided by RGD
Primary source: RGD:620717
See related: Ensembl:ENSRNOG00000015732 AllianceGenome:RGD:620717
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bclw; BCL-W; BCL-WS; BCL-WEL
Summary: Enables BH domain binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and negative regulation of release of cytochrome c from mitochondria. Located in mitochondrial membrane. Biomarker of Alzheimer's disease; epilepsy; pterygium; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human BCL2L2 (BCL2 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 171.4), Kidney (RPKM 125.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32326686..32337834)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28346449..28361627)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33543774..33549165)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells.
Title: Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells.
miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells.
Title: miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells.
Target-derived neurotrophins coordinate transcription of the antiapoptotic gene bclw with transport of bclw mRNA to the axon, and thereby prevent axonal degeneration in rat and mouse sensory neurons.
Title: Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration.
we verified that miR-29b directly targeted and inhibited Bcl2L2 gene expression
Title: Upregulated miR-29b promotes neuronal cell death by inhibiting Bcl2L2 after ischemic brain injury.
the first evidence of Bcl-w localization in the growth cones of differentiating neuronal cells was provided, suggestive of a potential synaptic neuroprotective role.
Title: Cloning and characterization of the 5'UTR of the rat anti-apoptotic Bcl-w gene.
E2 attenuates Abeta-induced neuronal death by Bcl-w upregulation & Bim downregulation, & by inhibition of Abeta-induced JNK activation & JNK-dependent downregulation of Bcl-w & upregulation of Bim, & mitochondrial release of cytochrome c & Smac.
Title: Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.
There is widespread bcl-w overexpression on both mRNA and protein levels in the bilateral cortex and in subcortical regions following photothrombotic ring stroke.
Title: Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats.
both Bcl-W mRNA and caspase 3 mRNA are expressed in isolated Sertoli cells of pre-puberal rat testes
Title: RNA expression bcl-w, a new related protein Bcl-2 family, and caspase-3 in isolated sertoli cells from pre-pubertal rat testes.
The mechanism of Abeta-induced neuronal apoptosis sequentially involves JNK activation, Bcl-w downregulation, and release of mitochondrial Smac, followed by cell death.
Title: Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bcl2l2 (e-PCR), detects polymorphism
- UniSTS:141169

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BH domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables BH domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Sertoli cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to amyloid-beta	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glycine	IEP Inferred from Expression Pattern more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial membrane permeability	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of Bcl-2 family protein complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bcl-2-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021850.2 → NP_068622.1 bcl-2-like protein 2

See identical proteins and their annotated locations for NP_068622.1

Status: PROVISIONAL

Source sequence(s)

BC074021

UniProtKB/TrEMBL

F7ELB1, O88996

Conserved Domains (1) summary

TIGR00865
Location:11 → 193

bcl-2; apoptosis regulator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

32326686..32337834

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274606.1 → XP_063130676.1 bcl-2-like protein 2 isoform X2
XM_063274607.1 → XP_063130677.1 bcl-2-like protein 2 isoform X3
XM_017599793.3 → XP_017455282.1 bcl-2-like protein 2 isoform X1

UniProtKB/TrEMBL

Q7TS60

Conserved Domains (3) summary

cd06845
Location:35 → 173

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:37 → 219

bcl-2; apoptosis regulator

pfam07336
Location:146 → 205

ABATE; Putative stress-induced transcription regulator