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    Rbm15b RNA binding motif protein 15B [ Mus musculus (house mouse) ]

    Gene ID: 109095, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rbm15bprovided by MGI
    Official Full Name
    RNA binding motif protein 15Bprovided by MGI
    Primary source
    MGI:MGI:1923598
    See related
    Ensembl:ENSMUSG00000074102 AllianceGenome:MGI:1923598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810017N16Rik
    Summary
    Predicted to enable mRNA binding activity. Involved in mRNA export from nucleus. Located in nuclear envelope and nuclear speck. Is expressed in central nervous system and sensory organ. Orthologous to human RBM15B (RNA binding motif protein 15B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    See Rbm15b in Genome Data Viewer
    Location:
    9 F1; 9 57.98 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106758127..106764274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106880928..106887075, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene testis expressed gene 264 ER-phagy receptor Neighboring gene STARR-seq mESC enhancer starr_25160 Neighboring gene RAD54 like 2 (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_25163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106723938-106724121 Neighboring gene STARR-positive B cell enhancer ABC_E8313 Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9334 Neighboring gene STARR-positive B cell enhancer ABC_E460 Neighboring gene dedicator of cyto-kinesis 3 Neighboring gene mesencephalic astrocyte-derived neurotrophic factor Neighboring gene predicted gene, 18542

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. Uranishi H, et al. J Biol Chem, 2009 Sep 18. PMID 19586903, Free PMC Article
    2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
      Title: The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dosage compensation by inactivation of X chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative RNA-binding protein 15B
    Names
    RNA binding motif protein 15 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175402.5 → NP_780611.3  putative RNA-binding protein 15B

      See identical proteins and their annotated locations for NP_780611.3

      Status: VALIDATED

      Source sequence(s)
      AC147636
      Consensus CDS
      CCDS52915.1
      UniProtKB/Swiss-Prot
      Q6PHZ5, Q8C6G2
      Related
      ENSMUSP00000059330.8, ENSMUST00000055843.9
      Conserved Domains (5) summary
      cd12554
      Location:134 → 215
      RRM1_RBM15B; RNA recognition motif 1 in putative RNA binding motif protein 15B (RBM15B) from vertebrate
      cd12556
      Location:325 → 409
      RRM2_RBM15B; RNA recognition motif 2 in putative RNA binding motif protein 15B (RBM15B) from vertebrate
      cd12558
      Location:412 → 487
      RRM3_RBM15B; RNA recognition motif 3 in putative RNA-binding protein 15B (RBM15B) from vertebrate
      pfam07744
      Location:719 → 854
      SPOC; SPOC domain
      pfam10500
      Location:568 → 712
      SR-25; Nuclear RNA-splicing-associated protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106758127..106764274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_020925.1: Suppressed sequence

      Description
      NG_020925.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PHZ5.2 GenPept UniProtKB/Swiss-Prot:Q6PHZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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