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    Snx8 sorting nexin 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288504, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Snx8provided by RGD
    Official Full Name
    sorting nexin 8provided by RGD
    Primary source
    RGD:1305791
    See related
    Ensembl:ENSRNOG00000001258 AllianceGenome:RGD:1305791
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and phosphatidylinositol binding activity. Predicted to be involved in early endosome to Golgi transport and intracellular protein transport. Predicted to be located in early endosome membrane. Predicted to be part of retromer complex. Orthologous to human SNX8 (sorting nexin 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 133.0), Spleen (RPKM 96.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx8 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19365746..19414333)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14251829..14300435)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16340917..16389500)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 19B Neighboring gene U6 spliceosomal RNA Neighboring gene eukaryotic translation initiation factor 3, subunit B Neighboring gene uncharacterized LOC108352425 Neighboring gene nudix hydrolase 1 Neighboring gene mitochondrial rRNA methyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sorting nexin 8 regulates endosome-to-Golgi transport. Dyve AB, et al. Biochem Biophys Res Commun, 2009 Dec 4. PMID 19782049
    2. Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. van Weering JR, et al. EMBO J, 2012 Nov 28. PMID 23085988, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105912.1 → NP_001099382.1  sorting nexin-8

      See identical proteins and their annotated locations for NP_001099382.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474012
      UniProtKB/TrEMBL
      A0A8I6A8L9, A6K1S7, D3ZUJ9
      Related
      ENSRNOP00000001696.3, ENSRNOT00000001696.4
      Conserved Domains (2) summary
      cd06866
      Location:70 → 173
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:190 → 438
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19365746..19414333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248920.5 → XP_006248982.1  sorting nexin-8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8L9
      Conserved Domains (2) summary
      cd06866
      Location:70 → 173
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:190 → 434
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

    2. XM_039089189.2 → XP_038945117.1  sorting nexin-8 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8L9
      Related
      ENSRNOP00000087776.1

    3. XM_006248921.5 → XP_006248983.1  sorting nexin-8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8L9
      Conserved Domains (2) summary
      cd06866
      Location:69 → 172
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:189 → 433
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

    RNA

    1. XR_010056367.1 RNA Sequence

    2. XR_010056368.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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