Ablim3 actin binding LIM protein family, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ablim3provided by RGD
Official Full Name: actin binding LIM protein family, member 3provided by RGD
Primary source: RGD:1565118
See related: Ensembl:ENSRNOG00000019365 AllianceGenome:RGD:1565118
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565118
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in cilium assembly; lamellipodium assembly; and positive regulation of protein targeting to mitochondrion. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in glutamatergic synapse and lamellipodium. Predicted to be active in stress fiber and synapse. Orthologous to human ABLIM3 (actin binding LIM protein family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 106.2), Heart (RPKM 71.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (57527917..57646936, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (55256135..55376629, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (57126534..57245965, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: actin-binding LIM protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191698.1 → NP_001178627.1 actin-binding LIM protein 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A0G2K875, A0A8I6AVJ1

Related

ENSRNOP00000074499.2, ENSRNOT00000080365.2

Conserved Domains (6) summary

smart00153
Location:648 → 683

VHP; Villin headpiece domain

cd09327
Location:23 → 74

LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins

cd09328
Location:79 → 134

LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins

cd09329
Location:151 → 202

LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins

cd09330
Location:210 → 265

LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins

pfam16182
Location:274 → 647

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM