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    Akap3 A-kinase anchoring protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312720, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Akap3provided by RGD
    Official Full Name
    A-kinase anchoring protein 3provided by RGD
    Primary source
    RGD:1359735
    See related
    Ensembl:ENSRNOG00000059227 AllianceGenome:RGD:1359735
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase A binding activity. Predicted to be involved in protein localization. Predicted to act upstream of or within blastocyst hatching and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in acrosomal vesicle; sperm fibrous sheath; and sperm midpiece. Predicted to be active in cytoplasm and sperm principal piece. Orthologous to human AKAP3 (A-kinase anchoring protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 673.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (161374198..161400062)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (159688049..159714067)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (159399686..159425512)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 Neighboring gene uncharacterized LOC134486843 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 4 Neighboring gene RAD51 associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia. Liu W, et al. J Genet Genomics, 2019 Jan 20. PMID 30745215
    2. Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. Vijayaraghavan S, et al. Mol Endocrinol, 1999 May. PMID 10319321
    3. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. Lea IA, et al. Reprod Biol Endocrinol, 2004 Jul 16. PMID 15257753, Free PMC Article
    4. A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Brown PR, et al. Biol Reprod, 2003 Jun. PMID 12606363
    5. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. Carr DW, et al. J Biol Chem, 2001 May 18. PMID 11278869

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93915

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm fibrous sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 3
    Names
    A kinase (PRKA) anchor protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005557.1 → NP_001005557.1  A-kinase anchor protein 3

      See identical proteins and their annotated locations for NP_001005557.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081924
      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6
      Related
      ENSRNOP00000072217.1, ENSRNOT00000086525.2
      Conserved Domains (1) summary
      smart00807
      Location:5 → 858
      AKAP_110; A-kinase anchor protein 110 kDa

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      161374198..161400062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107684.2 → XP_038963612.1  A-kinase anchor protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6
      Conserved Domains (1) summary
      smart00807
      Location:5 → 858
      AKAP_110; A-kinase anchor protein 110 kDa

    2. XM_006237492.5 → XP_006237554.1  A-kinase anchor protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006237554.1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6
      Conserved Domains (1) summary
      smart00807
      Location:5 → 858
      AKAP_110; A-kinase anchor protein 110 kDa

    3. XM_008763290.3 → XP_008761512.1  A-kinase anchor protein 3 isoform X1

      See identical proteins and their annotated locations for XP_008761512.1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6
      Conserved Domains (1) summary
      smart00807
      Location:5 → 858
      AKAP_110; A-kinase anchor protein 110 kDa

    4. XM_063286144.1 → XP_063142214.1  A-kinase anchor protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6

    5. XM_063286147.1 → XP_063142217.1  A-kinase anchor protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6

    6. XM_063286145.1 → XP_063142215.1  A-kinase anchor protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6

    7. XM_063286143.1 → XP_063142213.1  A-kinase anchor protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6

    8. XM_063286146.1 → XP_063142216.1  A-kinase anchor protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6

    9. XM_063286142.1 → XP_063142212.1  A-kinase anchor protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6

    10. XM_039107683.2 → XP_038963611.1  A-kinase anchor protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6
      Conserved Domains (1) summary
      smart00807
      Location:5 → 858
      AKAP_110; A-kinase anchor protein 110 kDa

    11. XM_017592653.3 → XP_017448142.1  A-kinase anchor protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6
      Conserved Domains (1) summary
      smart00807
      Location:5 → 858
      AKAP_110; A-kinase anchor protein 110 kDa

    12. XM_017592654.3 → XP_017448143.1  A-kinase anchor protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6
      Conserved Domains (1) summary
      smart00807
      Location:5 → 858
      AKAP_110; A-kinase anchor protein 110 kDa

    13. XM_006237489.4 → XP_006237551.1  A-kinase anchor protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006237551.1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6
      Conserved Domains (1) summary
      smart00807
      Location:5 → 858
      AKAP_110; A-kinase anchor protein 110 kDa

    14. XM_006237488.5 → XP_006237550.1  A-kinase anchor protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006237550.1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6
      Conserved Domains (1) summary
      smart00807
      Location:5 → 858
      AKAP_110; A-kinase anchor protein 110 kDa

    15. XM_008763289.4 → XP_008761511.1  A-kinase anchor protein 3 isoform X1

      See identical proteins and their annotated locations for XP_008761511.1

      UniProtKB/TrEMBL
      A0A0G2K2E9, Q66HC6
      Conserved Domains (1) summary
      smart00807
      Location:5 → 858
      AKAP_110; A-kinase anchor protein 110 kDa
    Nucleotide Protein Strain
    Heading Accession and Version

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