Krt71 keratin 71 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt71provided by MGI
Official Full Name: keratin 71provided by MGI
Primary source: MGI:MGI:1861586
See related: Ensembl:ENSMUSG00000051879 AllianceGenome:MGI:1861586
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ca; Cu; Cal4; mK6irs; Krt2-6g; mK6irs1
Summary: Predicted to be a structural constituent of cytoskeleton. Involved in hair follicle morphogenesis. Located in keratin filament. Is expressed in eyelid epithelium; hair inner root sheath; lung; and vibrissa. Used to study hypotrichosis 13. Human ortholog(s) of this gene implicated in hypotrichosis 13. Orthologous to human KRT71 (keratin 71). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 15 F2; 15 57.0 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101642384..101651532, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101733949..101743097, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Missense point mutations in Krt2-6g is associated with hair abnormalities
Title: Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71rco12 and Krt71rco13.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (17) 1 citation
Radiation induced (1)
Chemically induced (ENU) (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	TAS Traceable Author Statement more info
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytoskeleton organization	TAS Traceable Author Statement more info
involved_in hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	TAS Traceable Author Statement more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IDA Inferred from Direct Assay more info	PubMed
located_in keratin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 71

Names: CK-6G; CK-71; K6G; K71; caracul; cytokeratin-6G; cytokeratin-71; keratin complex 2, basic, gene 6g; keratin complex 2, gene 6g; keratin-6G; mK6irs1/Krt2-6g; type II inner root sheath-specific keratin-K6irs1; type-II keratin Kb34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019956.1 → NP_064340.1 keratin, type II cytoskeletal 71

See identical proteins and their annotated locations for NP_064340.1

Status: PROVISIONAL

Source sequence(s)

AB033744

Consensus CDS

CCDS27862.1

UniProtKB/Swiss-Prot

A0JLW9, Q7TPF3, Q9D0X6, Q9R0H5

Related

ENSMUSP00000023710.4, ENSMUST00000023710.6

Conserved Domains (3) summary

pfam00038
Location:130 → 443

Filament; Intermediate filament protein

pfam16208
Location:15 → 127

Keratin_2_head; Keratin type II head

cl19885
Location:189 → 424

Sec6; Exocyst complex component Sec6