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    Bmp3 bone morphogenetic protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25667, updated on 2-May-2024

    Summary

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    Official Symbol
    Bmp3provided by RGD
    Official Full Name
    bone morphogenetic protein 3provided by RGD
    Primary source
    RGD:2212
    See related
    Ensembl:ENSRNOG00000002381 AllianceGenome:RGD:2212
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PBMP3
    Summary
    Enables growth factor activity. Predicted to be involved in SMAD protein signal transduction and positive regulation of pathway-restricted SMAD protein phosphorylation. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in extracellular space and vesicle. Orthologous to human BMP3 (bone morphogenetic protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 36.3), Lung (RPKM 34.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    14p22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (11012564..11041282, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (10712489..10737153, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (12362912..12387572, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 1, pseudogene 4 Neighboring gene uncharacterized LOC134481716 Neighboring gene protein kinase cGMP-dependent 2 Neighboring gene cilia and flagella associated protein 299 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein S3a, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BMP3 expression in the adult rat CNS. Yamashita K, et al. Brain Res, 2016 Jul 15. PMID 27130896
    2. Expression and possible mechanisms of regulation of BMP3 in rat cranial sutures. Nacamuli RP, et al. Plast Reconstr Surg, 2005 Oct. PMID 16217479
    3. Bone morphogenetic protein 3 expression pattern in rat condylar cartilage, femoral cartilage and mandibular fracture callus. Zheng L, et al. Eur J Oral Sci, 2005 Aug. PMID 16048524
    4. Temporal and spatial expression of bone morphogenetic proteins in extracorporeal shock wave-promoted healing of segmental defect. Wang FS, et al. Bone, 2003 Apr. PMID 12689682
    5. Sequence and expression of bone morphogenetic protein 3 mRNA in prolonged cultures of fetal rat calvarial osteoblasts and in rat prostate adenocarcinoma PA III cells. Chen D, et al. DNA Cell Biol, 1995 Mar. PMID 7880444

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis.
      Title: Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis.
    2. Data indicate that bone morphogenetic protein-3 (BMP3) is widely expressed throughout the adult central nervous system, and its abundant expression in the adult brain strongly supports the idea that BMP3 plays important roles in the adult brain.
      Title: BMP3 expression in the adult rat CNS.
    3. Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.
      Title: Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.
    4. Bmp3 expression in a special layer of typical articular cartilage may be regulated by mechanical stress stimulation. We also found that Bmp3 was expressed in the periosteal layers of the bone segments near the fracture site during fracture healing.
      Title: Bone morphogenetic protein 3 expression pattern in rat condylar cartilage, femoral cartilage and mandibular fracture callus.
    5. BMP3 is expressed in rat cranial sutures in a temporal pattern suggesting involvement in cranial suture patency and fusion.
      Title: Expression and possible mechanisms of regulation of BMP3 in rat cranial sutures.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BMP receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables BMP receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cartilage development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bone morphogenetic protein 3
    Names
    BMP-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017105.1 → NP_058801.1  bone morphogenetic protein 3 precursor

      See identical proteins and their annotated locations for NP_058801.1

      Status: PROVISIONAL

      Source sequence(s)
      D63860
      UniProtKB/Swiss-Prot
      P49002
      UniProtKB/TrEMBL
      A0A8I6A2A8, A6K643
      Related
      ENSRNOP00000084580.1, ENSRNOT00000104172.1
      Conserved Domains (2) summary
      pfam00019
      Location:364 → 467
      TGF_beta; Transforming growth factor beta like domain
      pfam00688
      Location:46 → 203
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      11012564..11041282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272879.1 → XP_063128949.1  bone morphogenetic protein 3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49002.1 GenPept UniProtKB/Swiss-Prot:P49002

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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