Fgf6 fibroblast growth factor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgf6provided by RGD
Official Full Name: fibroblast growth factor 6provided by RGD
Primary source: RGD:620130
See related: Ensembl:ENSRNOG00000053662 AllianceGenome:RGD:620130
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fgf7b
Summary: Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of cell population proliferation; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within cartilage condensation and myoblast differentiation. Located in sarcolemma. Orthologous to human FGF6 (fibroblast growth factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 14.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (161541089..161549624)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (159854913..159863447)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (159563798..159572333)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF6 enhances muscle regeneration after nerve injury via ERK1/ERK2 activation.
Title: FGF6 enhances muscle regeneration after nerve injury by relying on ERK1/2 mechanism.

Submit: New GeneRIF Correction

General gene information

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Markers

GDB:214840 (e-PCR)
- UniSTS:156193

Fgf6 (e-PCR), detects polymorphism
- UniSTS:258272

Fgf6 (e-PCR), detects polymorphism
- UniSTS:143093

Fgf6 (e-PCR), detects polymorphism
- UniSTS:143094

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cartilage condensation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor 6

Names: fibroblast growth factor 7b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.