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    Pigh phosphatidylinositol glycan anchor biosynthesis, class H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362756, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Pighprovided by RGD
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Hprovided by RGD
    Primary source
    RGD:1311438
    See related
    Ensembl:ENSRNOG00000010914 AllianceGenome:RGD:1311438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be integral component of membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Orthologous to human PIGH (phosphatidylinositol glycan anchor biosynthesis class H). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 59.0), Brain (RPKM 56.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (103601369..103630214, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (97874903..97897188, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (102258621..102272826, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547797 Neighboring gene transmembrane protein 229B Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H1 Neighboring gene branched chain ketoacid dehydrogenase kinase, pseudogene 1 Neighboring gene arginase 2 Neighboring gene vesicle transport through interaction with t-SNAREs 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe R, et al. EMBO J, 2000 Aug 15. PMID 10944123, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase subunit H
    Names
    phosphatidylinositol glycan, class H
    NP_001102184.1
    NP_001388291.1
    XP_017449717.1
    XP_063118187.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108714.2 → NP_001102184.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform 1

      See identical proteins and their annotated locations for NP_001102184.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6ALA7, A6HCG2, D4A0Z0
      Related
      ENSRNOP00000014775.3, ENSRNOT00000014775.5
      Conserved Domains (1) summary
      pfam10181
      Location:89 → 158
      PIG-H; GPI-GlcNAc transferase complex, PIG-H component

    2. NM_001401362.1 → NP_001388291.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RNA

    1. NR_190558.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      103601369..103630214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594228.3 → XP_017449717.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALA7

    2. XM_063262117.1 → XP_063118187.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform X2

    RNA

    1. XR_010052119.1 RNA Sequence

    2. XR_010052120.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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