Ptpn5 protein tyrosine phosphatase, non-receptor type 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptpn5provided by RGD
Official Full Name: protein tyrosine phosphatase, non-receptor type 5provided by RGD
Primary source: RGD:3448
See related: Ensembl:ENSRNOG00000013981 AllianceGenome:RGD:3448
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: STEP
Summary: Enables several functions, including identical protein binding activity; mitogen-activated protein kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of intracellular protein transport; and regulation of protein phosphorylation. Located in several cellular components, including perikaryon; proximal dendrite; and synaptic vesicle. Used to study transient cerebral ischemia. Biomarker of transient cerebral ischemia. Orthologous to human PTPN5 (protein tyrosine phosphatase non-receptor type 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 86.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (106756896..106817369, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (97620638..97681186, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (103197918..103258309, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alterations of STEP46 and STEP61 Expression in the Rat Retina with Age and AMD-Like Retinopathy Development.
Title: Alterations of STEP46 and STEP61 Expression in the Rat Retina with Age and AMD-Like Retinopathy Development.
activation of synaptic NMDAR by bicuculline or D-serine results in the ubiquitination and proteasomal degradation of STEP61, and increased surface localization of GluN1/GluN2B receptors.
Title: Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP(61).
findings suggest that Src and STEP recruitment is contingent on differing intracellular Ca(2+) dynamics that dictate whether NMDAR function is augmented or depressed following M1R stimulation
Title: STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit.
It is involved in the etiology of several age-associated neurologic disorders linked to oxidative stress and is also known to play a role in neuroprotection by modulating glutamatergic transmission.
Title: Aging is associated with dimerization and inactivation of the brain-enriched tyrosine phosphatase STEP.
activity-dependent regulation of STEP61 and its substrates GluN2B and GluA2 may contribute to homeostatic stabilization of excitatory synapses.
Title: Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity.
The study provides further insight into the mechanisms of regulation of STEP61 and also offers a molecular basis for the Zn(2+)-induced sustained activation of ERK2.
Title: Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.
These results indicate that STEP61 is a novel substrate of parkin, although further studies are necessary to determine whether elevated STEP61 levels directly contribute to the pathophysiology of PD.
Title: STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.
The findings indicate a neuroprotective role of STEP and suggest a potential role of the STEP-derived peptide in stroke therapy.
Title: Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia.
Previously characterized pathways of STEP regulation via the NMDA receptor are generally conserved in mechanical injury, correlating the amount of STEP formed and the degree of cell death observed after lethal stretch injury.
Title: In vitro stretch injury induces time- and severity-dependent alterations of STEP phosphorylation and proteolysis in neurons.
Activation and levels of STEP are dependent on the duration and magnitude of NR2B-NMDA receptor stimulation.
Title: NR2B-NMDA receptor mediated modulation of the tyrosine phosphatase STEP regulates glutamate induced neuronal cell death.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U28216 (e-PCR)
- UniSTS:125709

U28217 (e-PCR)
- UniSTS:125710

SHGC-32421 (e-PCR)
- UniSTS:63522

RH132351 (e-PCR)
- UniSTS:215634

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in exploration behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of response to drug	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 5

Names: neural-specific protein-tyrosine phosphatase; protein-tyrosine phosphatase striatum-enriched; protein-tyrosine-phosphatase non-receptor 5; striatum-enriched protein-tyrosine phosphatase

NP_001385534.1

EC 3.1.3.48

XP_006229316.1

EC 3.1.3.48

XP_006229319.1

EC 3.1.3.48

XP_038965611.1

EC 3.1.3.48

XP_038965615.1

EC 3.1.3.48

XP_038965619.1

EC 3.1.3.48

XP_038965622.1

EC 3.1.3.48

XP_038965626.1

EC 3.1.3.48

XP_038965627.1

EC 3.1.3.48

XP_038965631.1

EC 3.1.3.48

XP_063143815.1

EC 3.1.3.48

XP_063143827.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398605.1 → NP_001385534.1 tyrosine-protein phosphatase non-receptor type 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2QC31

Related

ENSRNOP00000018860.6, ENSRNOT00000018860.7

Conserved Domains (1) summary

cd14613
Location:317 → 574

PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

106756896..106817369 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109694.2 → XP_038965622.1 tyrosine-protein phosphatase non-receptor type 5 isoform X2

Conserved Domains (1) summary

cd14613
Location:326 → 583

PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
XM_039109687.2 → XP_038965615.1 tyrosine-protein phosphatase non-receptor type 5 isoform X1

Conserved Domains (1) summary

cd14613
Location:346 → 603

PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
XM_063287757.1 → XP_063143827.1 tyrosine-protein phosphatase non-receptor type 5 isoform X5
XM_039109699.2 → XP_038965627.1 tyrosine-protein phosphatase non-receptor type 5 isoform X3

Conserved Domains (1) summary

cd14613
Location:318 → 575

PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
XM_039109691.2 → XP_038965619.1 tyrosine-protein phosphatase non-receptor type 5 isoform X2

Conserved Domains (1) summary

cd14613
Location:326 → 583

PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
XM_039109683.2 → XP_038965611.1 tyrosine-protein phosphatase non-receptor type 5 isoform X1

Conserved Domains (1) summary

cd14613
Location:346 → 603

PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
XM_039109703.2 → XP_038965631.1 tyrosine-protein phosphatase non-receptor type 5 isoform X4

Conserved Domains (1) summary

cd14613
Location:302 → 559

PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
XM_006229254.5 → XP_006229316.1 tyrosine-protein phosphatase non-receptor type 5 isoform X5

Conserved Domains (2) summary

smart00194
Location:298 → 551

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:324 → 551

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_006229257.5 → XP_006229319.1 tyrosine-protein phosphatase non-receptor type 5 isoform X6

Conserved Domains (2) summary

smart00194
Location:274 → 527

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:300 → 527

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_039109698.1 → XP_038965626.1 tyrosine-protein phosphatase non-receptor type 5 isoform X2

Conserved Domains (1) summary

cd14613
Location:326 → 583

PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
XM_063287745.1 → XP_063143815.1 tyrosine-protein phosphatase non-receptor type 5 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_019253.4: Suppressed sequence

Description

NM_019253.4: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.