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    Fcer2 Fc epsilon receptor II [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171075, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fcer2provided by RGD
    Official Full Name
    Fc epsilon receptor IIprovided by RGD
    Primary source
    RGD:619997
    See related
    Ensembl:ENSRNOG00000001005 AllianceGenome:RGD:619997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CD23; Fcer2a
    Summary
    Predicted to enable carbohydrate binding activity. Predicted to be involved in positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; and positive regulation of nitric-oxide synthase biosynthetic process. Predicted to act upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human FCER2 (Fc fragment of IgE receptor II). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 57.4), Heart (RPKM 28.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fcer2 in Genome Data Viewer
    Location:
    12p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (6540697..6552364, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1742809..1754476, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2233772..2245324, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene foxo1-corepressor-like Neighboring gene trafficking protein particle complex subunit 5 Neighboring gene C-type lectin domain family 4, member G Neighboring gene CD209a molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A role of IgE and CD23/NO immune pathway in age-related resistance of Lewis rats to Plasmodium berghei Anka? Safeukui I, et al. Microbes Infect, 2008 Oct. PMID 18761417
    2. The importance of Lys-352 of human immunoglobulin E in FcepsilonRII/CD23 recognition. Sayers I, et al. J Biol Chem, 2004 Aug 20. PMID 15199058
    3. Secretion of interleukin-1 receptor antagonist from human mast cells after immunoglobulin E-mediated activation and after segmental antigen challenge. Hagaman DD, et al. Am J Respir Cell Mol Biol, 2001 Dec. PMID 11726393
    4. Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy. Moura IC, et al. J Exp Med, 2001 Aug 20. PMID 11514599, Free PMC Article
    5. Identification of the Fcalpha/muR isoform specifically expressed in the kidney tubules. Kurita N, et al. Mol Immunol, 2009 Feb. PMID 19027165

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93219

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables IgE binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-affinity IgE receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Fc receptor-mediated immune complex endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Fc-epsilon receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological process involved in interspecies interaction between organisms IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    low affinity immunoglobulin epsilon Fc receptor
    Names
    Fc fragment of IgE receptor II
    Fc fragment of IgE, low affinity II, receptor for (CD23)
    Fc receptor alpha multiple ligand receptor
    Fc receptor, IgE, low affinity II, alpha polypeptide
    Fcalpha RII
    Fcalpha muR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033924.1 → NP_001029096.1  low affinity immunoglobulin epsilon Fc receptor isoform a

      See identical proteins and their annotated locations for NP_001029096.1

      Status: VALIDATED

      Source sequence(s)
      BC078749
      UniProtKB/TrEMBL
      F7EKM2, Q6AZ45, Q8R4T3
      Related
      ENSRNOP00000001332.4, ENSRNOT00000001332.7
      Conserved Domains (2) summary
      cd03590
      Location:186 → 306
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:60 → 170
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_133550.2 → NP_598234.2  low affinity immunoglobulin epsilon Fc receptor isoform b

      See identical proteins and their annotated locations for NP_598234.2

      Status: VALIDATED

      Source sequence(s)
      BC078749, X73579
      UniProtKB/TrEMBL
      A6KQ36, Q63097
      Related
      ENSRNOP00000001333.5, ENSRNOT00000001333.5
      Conserved Domains (2) summary
      cd03590
      Location:165 → 285
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:67 → 149
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      6540697..6552364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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