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    Amd1 adenosylmethionine decarboxylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81640, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Amd1provided by RGD
    Official Full Name
    adenosylmethionine decarboxylase 1provided by RGD
    Primary source
    RGD:2104
    See related
    AllianceGenome:RGD:2104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Amd1a; Amd1b
    Summary
    Enables adenosylmethionine decarboxylase activity and putrescine binding activity. Involved in S-adenosylmethionine metabolic process; spermidine biosynthetic process; and spermine biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 374.7), Kidney (RPKM 362.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    20q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (45250289..45324939, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (43695783..43711476, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (45384000..45399694, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC120098816 Neighboring gene vasculin-like protein 1 Neighboring gene transmembrane protein 258, pseudogene 3 Neighboring gene U6 spliceosomal RNA Neighboring gene cyclin-dependent kinase 19 Neighboring gene solute carrier family 22 member 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dysregulated gene expression predicts tumor aggressiveness in African-American prostate cancer patients. Ali HEA, et al. Sci Rep, 2018 Nov 5. PMID 30397274, Free PMC Article
    2. Conformational stabilization of rat s-adenosylmethionine decarboxylase by putrescine. Wada M, et al. Biol Pharm Bull, 2010. PMID 21048303
    3. Polyamine depletion delays apoptosis of rat intestinal epithelial cells. Ray RM, et al. Am J Physiol Cell Physiol, 2000 Mar. PMID 10712236
    4. Structures and chromosomal localizations of two rat genes encoding S-adenosylmethionine decarboxylase. Pulkka A, et al. Genomics, 1993 May. PMID 8314573
    5. Structure and organization of the gene encoding rat S-adenosylmethionine decarboxylase. Pulkka A, et al. FEBS Lett, 1991 Oct 21. PMID 1936275

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables adenosylmethionine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosylmethionine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosylmethionine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables putrescine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables putrescine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in polyamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermidine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-adenosylmethionine decarboxylase proenzyme
    Names
    S-Adenosylmethionine decarboxylase 1B
    S-adenosylmethionine decarboxylase 1
    S-adenosylmethionine decarboxylase 1A
    SAMDC
    adoMetDC
    NP_112273.3
    XP_063135627.1
    XP_063135628.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031011.4 → NP_112273.3  S-adenosylmethionine decarboxylase proenzyme

      See identical proteins and their annotated locations for NP_112273.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P17708
      UniProtKB/TrEMBL
      A6KII8
      Conserved Domains (1) summary
      pfam01536
      Location:4 → 325
      SAM_decarbox; Adenosylmethionine decarboxylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      45250289..45324939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279557.1 → XP_063135627.1  S-adenosylmethionine decarboxylase proenzyme isoform X1

      UniProtKB/Swiss-Prot
      P17708
      UniProtKB/TrEMBL
      A6KII8

    2. XM_063279558.1 → XP_063135628.1  S-adenosylmethionine decarboxylase proenzyme isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17708.3 GenPept UniProtKB/Swiss-Prot:P17708

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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