Fgf11 fibroblast growth factor 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Fgf11provided by RGD
Full Name: fibroblast growth factor 11provided by RGD
Primary source: RGD:620162
See related: Ensembl:ENSRNOG00000014882 AllianceGenome:RGD:620162
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fgf1d
Summary: Predicted to enable sodium channel regulator activity. Predicted to be involved in regulation of voltage-gated sodium channel activity. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Orthologous to human FGF11 (fibroblast growth factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 33.4), Spleen (RPKM 14.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55015232..55020773, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54516508..54522067, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56403320..56410816, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Fgf11 (e-PCR), detects polymorphism
- UniSTS:507914

Fgf11 (e-PCR), detects polymorphism
- UniSTS:546575

Fgf11 (e-PCR), detects polymorphism
- UniSTS:516627

Fgf11 (e-PCR), detects polymorphism
- UniSTS:258257

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 11

Names: fibroblast growth factor 1d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130816.1 → NP_570829.1 fibroblast growth factor 11

See identical proteins and their annotated locations for NP_570829.1

Status: PROVISIONAL

Source sequence(s)

AB079263

UniProtKB/TrEMBL

Q8R5L8

Conserved Domains (1) summary

smart00442
Location:69 → 199

FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

55015232..55020773 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596975.3 → XP_017452464.1 fibroblast growth factor 11 isoform X1

Conserved Domains (1) summary

smart00442
Location:69 → 199

FGF; Acidic and basic fibroblast growth factor family
XM_039085115.2 → XP_038941043.1 fibroblast growth factor 11 isoform X2

Conserved Domains (1) summary

cl00060
Location:69 → 171

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...