Srpra SRP receptor subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srpraprovided by RGD
Official Full Name: SRP receptor subunit alphaprovided by RGD
Primary source: RGD:1311504
See related: Ensembl:ENSRNOG00000010543 AllianceGenome:RGD:1311504
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Srpr
Summary: Predicted to enable GTPase activity and signal recognition particle binding activity. Predicted to be involved in protein targeting to ER. Predicted to be part of signal recognition particle receptor complex. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SRPRA (SRP receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 311.5), Kidney (RPKM 292.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (41818199..41824292)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (33560365..33566458)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (36410683..36416766)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131034 (e-PCR)
- UniSTS:214317

GDB:197863 (e-PCR)
- UniSTS:155977

UniSTS:236630 (e-PCR)
- UniSTS:236630

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables signal recognition particle binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of signal recognition particle receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal recognition particle receptor subunit alpha

Names: SRP receptor alpha subunit; signal recognition particle receptor ('docking protein')

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034150.2 → NP_001029322.1 signal recognition particle receptor subunit alpha

See identical proteins and their annotated locations for NP_001029322.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6JYJ9, Q3KRC3

Related

ENSRNOP00000015177.5, ENSRNOT00000015177.7

Conserved Domains (3) summary

cd17876
Location:417 → 633

SRalpha_C; C-terminal domain of signal recognition particle receptor alpha subunit

pfam02881
Location:316 → 387

SRP54_N; SRP54-type protein, helical bundle domain

pfam04086
Location:27 → 297

SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal