Caprin1 cell cycle associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Caprin1provided by RGD
Official Full Name: cell cycle associated protein 1provided by RGD
Primary source: RGD:1305707
See related: Ensembl:ENSRNOG00000009152 AllianceGenome:RGD:1305707
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpiap1; rng105; GPI p137
Summary: Enables RNA binding activity. Involved in negative regulation of translation. Located in P-body and cytoplasmic stress granule. Is active in glutamatergic synapse and postsynapse. Orthologous to human CAPRIN1 (cell cycle associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 882.7), Thymus (RPKM 757.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q32

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (110606489..110685408, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (90152305..90230447, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (93701830..93789580, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNG105 is a translational repressor in the RNA granules and provide insight into the link between RNG105 dynamics and local translational regulation.
Title: A novel RNA-binding protein in neuronal RNA granules: regulatory machinery for local translation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142945 (e-PCR)
- UniSTS:232192

RH79878 (e-PCR)
- UniSTS:86560

RH133345 (e-PCR)
- UniSTS:216628

RH128979 (e-PCR)
- UniSTS:212287

RH138024 (e-PCR)
- UniSTS:220111

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular function activator activity	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in generation of neurons	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within generation of neurons	ISO Inferred from Sequence Orthology more info
involved_in intracellular mRNA localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular mRNA localization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in non-membrane-bounded organelle assembly	IEA Inferred from Electronic Annotation more info
involved_in non-membrane-bounded organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stress granule assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress granule assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	IEA Inferred from Electronic Annotation more info
involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	ISO Inferred from Sequence Orthology more info
involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular non-membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caprin-1

Names: GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; RNA granule protein 105; cytoplasmic activation- and proliferation-associated protein 1; p137GPI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012185.3 → NP_001012185.2 caprin-1

See identical proteins and their annotated locations for NP_001012185.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

A9ZSZ9, Q5M9G3, Q6YF16

UniProtKB/TrEMBL

A6HNS6

Conserved Domains (2) summary

pfam12287
Location:357 → 679

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam18293
Location:130 → 245

Caprin-1_dimer; Caprin-1 dimerization domain
NM_001423164.1 → NP_001410093.1 caprin-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

A9ZSZ9, Q5M9G3, Q6YF16

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

110606489..110685408 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284152.1 → XP_063140222.1 caprin-1 isoform X1

UniProtKB/TrEMBL

A0A8L2Q6N7
XM_039105438.2 → XP_038961366.2 caprin-1 isoform X1

UniProtKB/TrEMBL

A0A8L2Q6N7
XM_006234652.4 → XP_006234714.1 caprin-1 isoform X2

UniProtKB/TrEMBL

A6HNS6

Conserved Domains (1) summary

pfam12287
Location:286 → 598

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term