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    Timm29 translocase of inner mitochondrial membrane 29 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315463, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Timm29provided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 29provided by RGD
    Primary source
    RGD:1309188
    See related
    AllianceGenome:RGD:1309188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309188
    Summary
    Predicted to enable protein transporter activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex. Orthologous to human TIMM29 (translocase of inner mitochondrial membrane 29). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 184.1), Muscle (RPKM 176.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Timm29 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28421370..28424339)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20145264..20148233)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22625874..22628843)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 19 open reading frame 38 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X, pseudogene 1 Neighboring gene transmembrane p24 trafficking protein 1 Neighboring gene coactivator-associated arginine methyltransferase 1 Neighboring gene Yip1 domain family, member 2 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Neighboring gene uncharacterized LOC134480145 Neighboring gene low density lipoprotein receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TIM29 is a subunit of the human carrier translocase required for protein transport. Callegari S, et al. FEBS Lett, 2016 Dec. PMID 27718247, Free PMC Article
    2. Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability. Kang Y, et al. Elife, 2016 Aug 24. PMID 27554484, Free PMC Article
    3. Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex. Kang Y, et al. Mol Cell, 2017 Aug 3. PMID 28712726
    4. Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Vukotic M, et al. Mol Cell, 2017 Aug 3. PMID 28712724
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim29
    Names
    uncharacterized protein C19orf52 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108129.1 → NP_001101599.1  mitochondrial import inner membrane translocase subunit Tim29

      See identical proteins and their annotated locations for NP_001101599.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473993
      UniProtKB/TrEMBL
      A6JNT6
      Conserved Domains (1) summary
      pfam10171
      Location:31 → 193
      DUF2366; uncharacterized conserved protein (DUF2366)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28421370..28424339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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