Cmpk1 cytidine/uridine monophosphate kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cmpk1provided by RGD
Official Full Name: cytidine/uridine monophosphate kinase 1provided by RGD
Primary source: RGD:1310116
See related: Ensembl:ENSRNOG00000007775 AllianceGenome:RGD:1310116
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CK; Cmpk; RGD1310116
Summary: Enables CMP kinase activity and uridylate kinase activity. Involved in ovulation cycle process; phthalate metabolic process; and pyrimidine nucleoside diphosphate biosynthetic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 517.7), Liver (RPKM 412.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (133717073..133744623, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (128480301..128507830, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (133759722..133786452, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Rat30 (e-PCR)
- UniSTS:118899

D5Got57 (e-PCR)
- UniSTS:114613

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CMP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables CMP kinase activity	IEA Inferred from Electronic Annotation more info
enables UMP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UMP kinase activity	IEA Inferred from Electronic Annotation more info
enables UMP kinase activity	ISO Inferred from Sequence Orthology more info
enables UMP/dUMP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables UMP/dUMP kinase activity	IEA Inferred from Electronic Annotation more info
enables cytidylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytidylate kinase activity	IEA Inferred from Electronic Annotation more info
enables dCMP kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleoside monophosphate kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in CDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dCDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dUDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in ovulation cycle process	IEP Inferred from Expression Pattern more info	PubMed
involved_in phthalate metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UMP-CMP kinase

Names: UMP-CMP kinase 1; UMP/CMPK; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; cytidine monophosphate kinase; cytidylate kinase; dCMP kinase; deoxycytidylate kinase; nucleoside-diphosphate kinase; uridine monophosphate kinase; uridine monophosphate/cytidine monophosphate kinase

NP_001020826.1

EC 2.7.4.14

EC 2.7.4.6

XP_063143469.1

EC 2.7.4.14

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.