Oga O-GlcNAcase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ogaprovided by RGD
Full Name: O-GlcNAcaseprovided by RGD
Primary source: RGD:621077
See related: Ensembl:ENSRNOG00000017822 AllianceGenome:RGD:621077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mgea5; Ncoat
Summary: Enables beta-N-acetylglucosaminidase activity and histone acetyltransferase activity. Involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of cellular protein metabolic process. Located in mitochondrion. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 586.9), Adrenal (RPKM 445.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (254547311..254589596, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (244598285..244633835, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (265506752..265542452, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work identifies the first target of miR-539 in the heart and the first miRNA that regulates OGA.
Title: MicroRNA-539 is up-regulated in failing heart, and suppresses O-GlcNAcase expression.
protein O-GlcNAcylation, OGT, and OGA in the rat brain at various ages from embryonic day 15 to the age of 2 years
Title: Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain.
present results provide definitive evidence that O-GlcNAcase antagonizes posthypoxic cardiac myocyte survival
Title: Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury.
Together, these data demonstrate that alloxan is an inhibitor of O-GlcNAc-selective N-acetyl-beta-d-glucosaminidase, with inhibition corresponding to an altered tryptic digest pattern of N-terminal active site peptides.
Title: Alloxan is an inhibitor of O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase.
Streptozotocin inhibition of O-GlcNAcase induces an insulin secretory defect in isolated rat islet cells, and a growth hormone secretory defect, and impairment of intracellular secretory vesicle trafficking.
Title: Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone secretion.
NCOAT may be regulated to reduce the state of glycosylation of transcriptional activators while increasing the acetylation of histones to allow for the concerted activation of eukaryotic gene transcription
Title: Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132562 (e-PCR)
- UniSTS:215845

RH138718 (e-PCR)
- UniSTS:220805

RH132954 (e-PCR)
- UniSTS:216237

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity	IEA Inferred from Electronic Annotation more info
enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity	ISO Inferred from Sequence Orthology more info
enables beta-N-acetylglucosaminidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-N-acetylglucosaminidase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-N-acetylglucosaminidase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in N-acetylglucosamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in N-acetylglucosamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate derivative metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dATP metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycoprotein metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cardiac muscle adaptation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell killing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein-containing complex disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein O-GlcNAcase

Names: N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; beta-N-acetylhexosaminidase; beta-hexosaminidase; bifunctional protein NCOAT; meningioma expressed antigen 5 (hyaluronidase); meningioma-expressed antigen 5; nuclear cytoplasmic O-GlcNAcase and acetyltransferase; protein O-GlcNAcase-like

NP_571979.1

EC 3.2.1.169

XP_017444197.1

EC 3.2.1.169

XP_063127739.1

EC 3.2.1.169

XP_063127766.1

EC 3.2.1.169

XP_063127795.1

EC 3.2.1.169

XP_063127835.1

EC 3.2.1.169

XP_063127855.1

EC 3.2.1.169

XP_063127887.1

EC 3.2.1.169

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.