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    Snx11 sorting nexin 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303493, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Snx11provided by RGD
    Official Full Name
    sorting nexin 11provided by RGD
    Primary source
    RGD:1307319
    See related
    Ensembl:ENSRNOG00000008642 AllianceGenome:RGD:1307319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in vesicle organization. Predicted to be located in endosome. Orthologous to human SNX11 (sorting nexin 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 79.6), Kidney (RPKM 55.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx11 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82238475..82249264, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81742020..81752778, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84628420..84639125, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene src kinase associated phosphoprotein 1 Neighboring gene uncharacterized LOC120095286 Neighboring gene uncharacterized LOC102551165 Neighboring gene uncharacterized LOC134480860 Neighboring gene chromobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. Xu J, et al. J Biol Chem, 2013 Jun 7. PMID 23615901, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012012.2 → NP_001012012.2  sorting nexin-11

      See identical proteins and their annotated locations for NP_001012012.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC086543, CO558022, DN932564
      UniProtKB/TrEMBL
      A0A8I5Y9D6, A6HIG1, D4A3W4
      Related
      ENSRNOP00000011474.4, ENSRNOT00000011474.7
      Conserved Domains (1) summary
      cd06898
      Location:18 → 129
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    2. NM_001199169.1 → NP_001186098.1  sorting nexin-11

      See identical proteins and their annotated locations for NP_001186098.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC086543, CO558022, DN932564
      UniProtKB/TrEMBL
      A0A8I5Y9D6, A6HIG1, D4A3W4
      Related
      ENSRNOP00000077201.1, ENSRNOT00000096544.1
      Conserved Domains (1) summary
      cd06898
      Location:18 → 129
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82238475..82249264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247196.4 → XP_006247258.1  sorting nexin-11 isoform X1

      See identical proteins and their annotated locations for XP_006247258.1

      UniProtKB/TrEMBL
      A0A8I5Y9D6, A6HIG1, D4A3W4
      Conserved Domains (1) summary
      cd06898
      Location:18 → 129
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    2. XM_006247198.4 → XP_006247260.1  sorting nexin-11 isoform X1

      See identical proteins and their annotated locations for XP_006247260.1

      UniProtKB/TrEMBL
      A0A8I5Y9D6, A6HIG1, D4A3W4
      Conserved Domains (1) summary
      cd06898
      Location:18 → 129
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    3. XM_063269114.1 → XP_063125184.1  sorting nexin-11 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y9D6, A6HIG1, D4A3W4

    4. XM_039086077.2 → XP_038942005.1  sorting nexin-11 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JXH9, Q5RJQ6
      Conserved Domains (1) summary
      cl02563
      Location:18 → 76
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein Strain
    Heading Accession and Version

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